Diacylglycerols as biomarkers of sustained immune activation in Proteinopathies associated with dementia

Paul L. Wood, John E. Cebak, Randall (Randy) Woltjer

Research output: Contribution to journalReview article

Abstract

Cognitive decline is a devastating clinical condition, heavily correlated with age progression. In the cases of Alzheimer's disease, Parkinson's disease, and Lewy body disease, the common neuropathologies are proteinopathies and neuroinflammation. Herein, we review current lipidomics findings and conclude that brain and circulating diacylglycerols represent biomarkers of this ongoing sustained immune response, presumably involving microglia. We further hypothesize that a logical next step will be to evaluate biomarkers of immune activation in a cohort of patients with Mild Cognitive Impairment (MCI) and subsequently attempt to provide therapeutic intervention with anti-inflammatory therapy in MCI patients with immune activation. Although this is an urgent and theoretically safe therapeutic trial, it will likely necessitate government support.

Original languageEnglish (US)
Pages (from-to)107-110
Number of pages4
JournalClinica Chimica Acta
Volume476
DOIs
StatePublished - Jan 1 2018

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Keywords

  • Cognitive dysfunction
  • Diacylglycerols
  • Immune activation
  • Neuroinflammation
  • Proteinopathies

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

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