Diabetes mellitus preserves synaptic plasticity in hippocampal slices from middle-aged rats

S. Tekkök, K. Krnjević

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Synaptic plasticity is generally believed to provide a cellular mechanism for learning and memory. One manifestation of synaptic plasticity, long-term potentiation in the CA1 region, was compared in hippocampal slices from young and older rats, both control animals and streptozotocin-treated diabetics with moderate hyperglycemia (≃ 15 mM). Long-term potentiation of excitatory synaptic potentials, elicited by tetanic stimulation or by 2- deoxy-D-glucose application, was readily obtained in slices from young (four- month-old) control and diabetic rats, but not in slices from middle-aged (12- month-old) control rats. Both forms of potentiation, however, could be elicited in slices from 12-month-old diabetics. The unexpected finding that long-term potentiation is restored in moderately hyperglycemic older rats suggests that the blood glucose level of older animals may be important for synaptic plasticity and perhaps for the ability to learn.

Original languageEnglish (US)
Pages (from-to)185-191
Number of pages7
JournalNeuroscience
Volume91
Issue number1
DOIs
StatePublished - Jun 1999
Externally publishedYes

Keywords

  • 2-deoxy-D-glucose
  • CA1
  • Cytosolic Ca
  • Long-term potentiation (LTP)
  • Post- tetanic potentiation (PTP)
  • Streptozotocin

ASJC Scopus subject areas

  • Neuroscience(all)

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