Diabetes Mellitus and Optic Atrophy: With Associated Findings of Diabetes Insipidus and Neurosensory Hearing Loss in Two Siblings

John L. Marquardt, D. Lynn Loriaux

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Two siblings had diabetes mellitus, diabetes insipidus, and optic atrophy. Abnormal findings include color blindness, neurosensory hearing loss, hyposmia, thermoregulatory failure in both hot and cold environments, electroencephalographic epileptiform activity, partial diabetes insipidus, blunted plasma cortisol response to pyrogen infusion, and aminoaciduria, predominantly of alanine. We propose a clinical entity consisting of bilateral optic atrophy, diabetes mellitus, diabetes insipidus, neurosensory hearing deficit, and hypothalamic dysfunction of variable degree.

Original languageEnglish (US)
Pages (from-to)32-37
Number of pages6
JournalArchives of internal medicine
Volume134
Issue number1
DOIs
StatePublished - Jul 1974

ASJC Scopus subject areas

  • Internal Medicine

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