TY - JOUR
T1 - Diabetes Mellitus and Optic Atrophy
T2 - With Associated Findings of Diabetes Insipidus and Neurosensory Hearing Loss in Two Siblings
AU - Marquardt, John L.
AU - Loriaux, D. Lynn
N1 - Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 1974/7
Y1 - 1974/7
N2 - Two siblings had diabetes mellitus, diabetes insipidus, and optic atrophy. Abnormal findings include color blindness, neurosensory hearing loss, hyposmia, thermoregulatory failure in both hot and cold environments, electroencephalographic epileptiform activity, partial diabetes insipidus, blunted plasma cortisol response to pyrogen infusion, and aminoaciduria, predominantly of alanine. We propose a clinical entity consisting of bilateral optic atrophy, diabetes mellitus, diabetes insipidus, neurosensory hearing deficit, and hypothalamic dysfunction of variable degree.
AB - Two siblings had diabetes mellitus, diabetes insipidus, and optic atrophy. Abnormal findings include color blindness, neurosensory hearing loss, hyposmia, thermoregulatory failure in both hot and cold environments, electroencephalographic epileptiform activity, partial diabetes insipidus, blunted plasma cortisol response to pyrogen infusion, and aminoaciduria, predominantly of alanine. We propose a clinical entity consisting of bilateral optic atrophy, diabetes mellitus, diabetes insipidus, neurosensory hearing deficit, and hypothalamic dysfunction of variable degree.
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U2 - 10.1001/archinte.1974.00320190034003
DO - 10.1001/archinte.1974.00320190034003
M3 - Article
C2 - 4545995
AN - SCOPUS:0016212125
SN - 0003-9926
VL - 134
SP - 32
EP - 37
JO - Archives of internal medicine
JF - Archives of internal medicine
IS - 1
ER -