Diabetes is associated with cerebrovascular but not Alzheimer's disease neuropathology

Erin L. Abner, Peter T. Nelson, Richard J. Kryscio, Frederick A. Schmitt, David W. Fardo, Randall (Randy) Woltjer, Nigel J. Cairns, Lei Yu, Hiroko Dodge, Chengjie Xiong, Kamal Masaki, Suzanne L. Tyas, David A. Bennett, Julie A. Schneider, Zoe Arvanitakis

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

Introduction: The relationship of diabetes to specific neuropathologic causes of dementia is incompletely understood. Methods: We used logistic regression to evaluate the association between diabetes and infarcts, Braak neurofibrillary tangle stage, and neuritic plaque score in 2365 autopsied persons. In a subset of >1300 persons with available cognitive data, we examined the association between diabetes and cognition using Poisson regression. Results: Diabetes increased odds of brain infarcts (odds ratio [OR] = 1.57, P <.0001), specifically lacunes (OR = 1.71, P <.0001), but not Alzheimer's disease neuropathology. Diabetes plus infarcts was associated with lower cognitive scores at end of life than infarcts or diabetes alone, and diabetes plus high level of Alzheimer's neuropathologic changes was associated with lower mini-mental state examination scores than the pathology alone. Discussion: This study supports the conclusions that diabetes increases the risk of cerebrovascular but not Alzheimer's disease pathology, and at least some of diabetes' relationship to cognitive impairment may be modified by neuropathology.

Original languageEnglish (US)
JournalAlzheimer's and Dementia
DOIs
StateAccepted/In press - 2016

Fingerprint

Alzheimer Disease
Odds Ratio
Pathology
Neurofibrillary Tangles
Amyloid Plaques
Cognition
Dementia
Logistic Models
Brain
Neuropathology
Cognitive Dysfunction

Keywords

  • Alzheimer
  • Autopsy
  • Cerebrovascular
  • Cognition
  • Diabetes
  • Infarcts
  • Neuropathology

ASJC Scopus subject areas

  • Clinical Neurology
  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Epidemiology
  • Health Policy

Cite this

Abner, E. L., Nelson, P. T., Kryscio, R. J., Schmitt, F. A., Fardo, D. W., Woltjer, R. R., ... Arvanitakis, Z. (Accepted/In press). Diabetes is associated with cerebrovascular but not Alzheimer's disease neuropathology. Alzheimer's and Dementia. https://doi.org/10.1016/j.jalz.2015.12.006

Diabetes is associated with cerebrovascular but not Alzheimer's disease neuropathology. / Abner, Erin L.; Nelson, Peter T.; Kryscio, Richard J.; Schmitt, Frederick A.; Fardo, David W.; Woltjer, Randall (Randy); Cairns, Nigel J.; Yu, Lei; Dodge, Hiroko; Xiong, Chengjie; Masaki, Kamal; Tyas, Suzanne L.; Bennett, David A.; Schneider, Julie A.; Arvanitakis, Zoe.

In: Alzheimer's and Dementia, 2016.

Research output: Contribution to journalArticle

Abner, EL, Nelson, PT, Kryscio, RJ, Schmitt, FA, Fardo, DW, Woltjer, RR, Cairns, NJ, Yu, L, Dodge, H, Xiong, C, Masaki, K, Tyas, SL, Bennett, DA, Schneider, JA & Arvanitakis, Z 2016, 'Diabetes is associated with cerebrovascular but not Alzheimer's disease neuropathology', Alzheimer's and Dementia. https://doi.org/10.1016/j.jalz.2015.12.006
Abner, Erin L. ; Nelson, Peter T. ; Kryscio, Richard J. ; Schmitt, Frederick A. ; Fardo, David W. ; Woltjer, Randall (Randy) ; Cairns, Nigel J. ; Yu, Lei ; Dodge, Hiroko ; Xiong, Chengjie ; Masaki, Kamal ; Tyas, Suzanne L. ; Bennett, David A. ; Schneider, Julie A. ; Arvanitakis, Zoe. / Diabetes is associated with cerebrovascular but not Alzheimer's disease neuropathology. In: Alzheimer's and Dementia. 2016.
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AU - Woltjer, Randall (Randy)

AU - Cairns, Nigel J.

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AU - Dodge, Hiroko

AU - Xiong, Chengjie

AU - Masaki, Kamal

AU - Tyas, Suzanne L.

AU - Bennett, David A.

AU - Schneider, Julie A.

AU - Arvanitakis, Zoe

PY - 2016

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