DHEA as a biomarker of aging in humans and nonhuman primates: Synthesis, neuroprotection, and cognitive function

    Research output: Chapter in Book/Report/Conference proceedingChapter

    1 Scopus citations

    Abstract

    Dehydroepiandrosterone (DHEA) and its sulfated ester (DHEAS) are two of the most abundant steroid hormones in the human circulation. Like cortisol, they are produced by the adrenal cortex and released into the circulation in a circadian pattern. Although the exact physiological roles of DHEA(S) are unclear, some of their actions may stem from intracrine conversion of DHEA(S) to estradiol within specific tissues, including cognitive brain centers. Importantly, circulating DHEA(S) concentrations decrease markedly during aging, and this decrease has been implicated in the cause of age-associated cognitive decline. However, although correlations have been demonstrated between circulating DHEA(S) concentrations and cognitive ability in certain human patient populations, such correlations have yet to be convincingly demonstrated during normal aging. Furthermore, despite DHEA being widely available in the United States, as a food supplement, there is little evidence supporting the view that physiological doses of exogenous DHEA can improve cognitive function in the elderly.

    Original languageEnglish (US)
    Title of host publicationAssessments, Treatments and Modeling in Aging and Neurological Disease
    Subtitle of host publicationThe Neuroscience of Aging
    PublisherElsevier
    Pages269-278
    Number of pages10
    ISBN (Electronic)9780128180006
    DOIs
    StatePublished - Jan 1 2021

    Keywords

    • Adrenalsteroids
    • Caloric restriction
    • Circadian
    • Cognitive decline
    • Cortisol
    • Dehydroepiandrosterone
    • Hormone replacement
    • Intracrinology
    • Menopause
    • Neurosteroidogenesis

    ASJC Scopus subject areas

    • Medicine(all)
    • Neuroscience(all)

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