Dexy's midnight spinal: Dexmedetomidine, bupivaine spinal, multiple mechanisms, CYP3A4, CYP2D6

Michael P. Hutchens; Edward A. Kahl; Matthias J. Merkel

doi:10.1007/978-1-4614-7495-1_35

Dexy's midnight spinal: Dexmedetomidine, bupivaine spinal, multiple mechanisms, CYP3A4, CYP2D6

Michael P. Hutchens, Edward A. Kahl, Matthias J. Merkel

Anesthesiology and Perioperative Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

This case discusses a possible pharmacokinetic interaction between bupivacaine and dexmedetomidine. Bupivacaine is a cytochrome P 450 2D6 and cytochrome 3A4 substrate. Dexmedetomidine has been shown, in vitro, to inhibit both enzymes.

Original language	English (US)
Title of host publication	A Case Approach to Perioperative Drug-Drug Interactions
Publisher	Springer New York
Pages	179-182
Number of pages	4
ISBN (Electronic)	9781461474951
ISBN (Print)	9781461474944
DOIs	https://doi.org/10.1007/978-1-4614-7495-1_35
State	Published - Sep 15 2015

ASJC Scopus subject areas

General Medicine

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10.1007/978-1-4614-7495-1_35

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abstract = "This case discusses a possible pharmacokinetic interaction between bupivacaine and dexmedetomidine. Bupivacaine is a cytochrome P 450 2D6 and cytochrome 3A4 substrate. Dexmedetomidine has been shown, in vitro, to inhibit both enzymes.",

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Dexy's midnight spinal: Dexmedetomidine, bupivaine spinal, multiple mechanisms, CYP3A4, CYP2D6

Abstract

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