Dexy's midnight spinal: Dexmedetomidine, bupivaine spinal, multiple mechanisms, CYP3A4, CYP2D6

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This case discusses a possible pharmacokinetic interaction between bupivacaine and dexmedetomidine. Bupivacaine is a cytochrome P 450 2D6 and cytochrome 3A4 substrate. Dexmedetomidine has been shown, in vitro, to inhibit both enzymes.

Original languageEnglish (US)
Title of host publicationA Case Approach to Perioperative Drug-Drug Interactions
PublisherSpringer New York
Pages179-182
Number of pages4
ISBN (Print)9781461474951, 9781461474944
DOIs
StatePublished - Sep 15 2015

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Hutchens, M., Kahl, E. E., & Merkel, M. (2015). Dexy's midnight spinal: Dexmedetomidine, bupivaine spinal, multiple mechanisms, CYP3A4, CYP2D6. In A Case Approach to Perioperative Drug-Drug Interactions (pp. 179-182). Springer New York. https://doi.org/10.1007/978-1-4614-7495-1_35