Dexy's midnight spinal

Dexmedetomidine, bupivaine spinal, multiple mechanisms, CYP3A4, CYP2D6

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This case discusses a possible pharmacokinetic interaction between bupivacaine and dexmedetomidine. Bupivacaine is a cytochrome P 450 2D6 and cytochrome 3A4 substrate. Dexmedetomidine has been shown, in vitro, to inhibit both enzymes.

Original languageEnglish (US)
Title of host publicationA Case Approach to Perioperative Drug-Drug Interactions
PublisherSpringer New York
Pages179-182
Number of pages4
ISBN (Print)9781461474951, 9781461474944
DOIs
StatePublished - Sep 15 2015

Fingerprint

Dexmedetomidine
Cytochrome P-450 CYP3A
Cytochrome P-450 CYP2D6
Bupivacaine
Cytochromes
Cytochrome P-450 Enzyme System
Pharmacokinetics
Enzymes
In Vitro Techniques

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hutchens, M., Kahl, E. E., & Merkel, M. (2015). Dexy's midnight spinal: Dexmedetomidine, bupivaine spinal, multiple mechanisms, CYP3A4, CYP2D6. In A Case Approach to Perioperative Drug-Drug Interactions (pp. 179-182). Springer New York. https://doi.org/10.1007/978-1-4614-7495-1_35

Dexy's midnight spinal : Dexmedetomidine, bupivaine spinal, multiple mechanisms, CYP3A4, CYP2D6. / Hutchens, Michael; Kahl, Edward (Ed); Merkel, Matthias.

A Case Approach to Perioperative Drug-Drug Interactions. Springer New York, 2015. p. 179-182.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hutchens, M, Kahl, EE & Merkel, M 2015, Dexy's midnight spinal: Dexmedetomidine, bupivaine spinal, multiple mechanisms, CYP3A4, CYP2D6. in A Case Approach to Perioperative Drug-Drug Interactions. Springer New York, pp. 179-182. https://doi.org/10.1007/978-1-4614-7495-1_35
Hutchens M, Kahl EE, Merkel M. Dexy's midnight spinal: Dexmedetomidine, bupivaine spinal, multiple mechanisms, CYP3A4, CYP2D6. In A Case Approach to Perioperative Drug-Drug Interactions. Springer New York. 2015. p. 179-182 https://doi.org/10.1007/978-1-4614-7495-1_35
Hutchens, Michael ; Kahl, Edward (Ed) ; Merkel, Matthias. / Dexy's midnight spinal : Dexmedetomidine, bupivaine spinal, multiple mechanisms, CYP3A4, CYP2D6. A Case Approach to Perioperative Drug-Drug Interactions. Springer New York, 2015. pp. 179-182
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