Dexmedetomidine does not attenuate increases in excitatory amino acids after transient global ischemia in the rabbit

Hae Kyu Kim, Mark Zornow, Martin A P Strnat, Mervyn Maze

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

This study was designed to evaluate the ability of dexmedetomidine, an α2-adrenergic agonist, to attenuate increases in the hippocampal concentration of extracellular glutamate and glycine that result from episodes of transient global cerebral ischemia. After the induction of anesthesia with halothane and oxygen, microdialysis catheters were stereotactically inserted into the hippocampi of 16 New Zealand white rabbits. After the collection of baseline samples of dialysate, animals were randomly assigned to receive an intravenous infusion of either saline (n = 8) or dexmedetomidine (n = 8). Transient global cerebral ischemia was produced by the inflation of a neck tourniquet and induction of deliberate hypotension for 10 min. Dialysates were collected during the ischemic period and for the ensuing 60 min of reperfusion. During ischemia, the concentrations of glutamate and glycine increased from the preischemic baseline in both groups. Glutamate concentrations rapidly returned to baseline after reperfusion, whereas glycine concentrations remained elevated throughout the reperfusion period. There were no significant differences between the control and dexmedetomidine-treated groups. These results suggest that the mechanism of the putative neuroprotective effects of dexmedetomidine is not related to decreased concentrations of glutamate or glycine.

Original languageEnglish (US)
Pages (from-to)230-235
Number of pages6
JournalJournal of Neurosurgical Anesthesiology
Volume8
Issue number3
StatePublished - 1996
Externally publishedYes

Fingerprint

Dexmedetomidine
Excitatory Amino Acids
Glycine
Glutamic Acid
Ischemia
Rabbits
Reperfusion
Dialysis Solutions
Transient Ischemic Attack
Tourniquets
Adrenergic Agonists
Microdialysis
Economic Inflation
Neuroprotective Agents
Halothane
Intravenous Infusions
Hypotension
Hippocampus
Neck
Catheters

Keywords

  • α-Adrenergic agonist
  • Dexmedetomidine
  • Excitatory amino acids
  • Global cerebral ischemia
  • Microdialysis
  • Rabbit

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Clinical Neurology

Cite this

Dexmedetomidine does not attenuate increases in excitatory amino acids after transient global ischemia in the rabbit. / Kim, Hae Kyu; Zornow, Mark; Strnat, Martin A P; Maze, Mervyn.

In: Journal of Neurosurgical Anesthesiology, Vol. 8, No. 3, 1996, p. 230-235.

Research output: Contribution to journalArticle

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