Developments in understanding neuronal spike trains and functional specializations in brain regions

Roberto A. Santiago, James McNames, Kim Burchiel, George G. Lendaris

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Understanding information processing at the neuronal level would provide valuable insights to computational intelligence research and computational neuroscience. In particular, understanding constraints on neuronal spike trains would provide indication about the type of syntactic rules used by neurons when processing information. A recent discovery, reported here, was made through analyzing microelectrode recordings (MER) made during surgical procedure in humans. Analysis of MERs of extracellular neuronal activity has gained increasing interest due to potential improvements to surgical techniques involving ablation or placement of deep brain stimulators, done in the treatment of advanced Parkinson's disease. Important to these procedures is the identification of different brain structures such as the globus pallidus internus from the spike train being recorded from the intracranial probe tip during surgery. Spike train data gathered during surgical procedure from multiple patients were processed using a novel feature extraction method reported here. Distinct structures within the spike trains were identified and used to build an effective brain region classifier. The extracted features upon analysis provide some insight into the 'syntactic' constraint on spike trains.

Original languageEnglish (US)
Pages (from-to)601-607
Number of pages7
JournalNeural Networks
Volume16
Issue number5-6
DOIs
StatePublished - Jun 2003

Fingerprint

Brain
Syntactics
Automatic Data Processing
Microelectrodes
Ablation Techniques
Ablation
Surgery
Neurons
Globus Pallidus
Artificial intelligence
Feature extraction
Artificial Intelligence
Classifiers
Neurosciences
Parkinson Disease
Research
Therapeutics

Keywords

  • Globus pallidus internus
  • Microelectrode recordings
  • Spike trains

ASJC Scopus subject areas

  • Artificial Intelligence
  • Neuroscience(all)

Cite this

Developments in understanding neuronal spike trains and functional specializations in brain regions. / Santiago, Roberto A.; McNames, James; Burchiel, Kim; Lendaris, George G.

In: Neural Networks, Vol. 16, No. 5-6, 06.2003, p. 601-607.

Research output: Contribution to journalArticle

Santiago, Roberto A. ; McNames, James ; Burchiel, Kim ; Lendaris, George G. / Developments in understanding neuronal spike trains and functional specializations in brain regions. In: Neural Networks. 2003 ; Vol. 16, No. 5-6. pp. 601-607.
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