Developmentally regulated expression of α6 integrin in avian embryos

Marianne Bronner-Fraser, Michael Artinger, John Muschler, Alan F. Horwitz

Research output: Contribution to journalArticle

109 Citations (Scopus)

Abstract

The distribution pattern of the avian α6 integrin subunit was examined during early stages of development. The results show that this subunit is prevalent in cells of the developing nervous system and muscle. α6 is first observed on neuroepithelial cells of the cranial neural plate and trunk neural tube. With time, immunoreactivity becomes prominent near the lumen and ventrolateral portions of the neural tube, co-distributing with neurons and axons, particularly notable on commissural neurons. The α6 expression pattern is dynamic in the neural tube, with immunoreactivity peaking by embryonic day 6 (stage 30) and decreasing thereafter. The ventral roots and retina exhibit high levels of immunoreactivity throughout development. In the peripheral nervous system, α6 immunoreactivity first appears on a subpopulation of sympathoadrenal cells around the dorsal aorta and later in the dorsal root ganglia shortly after gangliogenesis. Immunoreactivity appears on prospective myotomal cells as the somites delaminate into the dermomyotome and sclerotome, remaining prominent on myoblasts and differentiated muscle at all stages. The mesonephros also has intense immunoreactivity. In the periphery, α6 immunoreactive regions often in proximity to laminin, which is thought to be the ligand of α6β1 integrin.

Original languageEnglish (US)
Pages (from-to)197-211
Number of pages15
JournalDevelopment
Volume115
Issue number1
StatePublished - May 1992
Externally publishedYes

Fingerprint

Neural Tube
Integrins
Embryonic Structures
Mesonephros
Neuroepithelial Cells
Neural Plate
Neurons
Muscles
Somites
Spinal Nerve Roots
Myoblasts
Peripheral Nervous System
Spinal Ganglia
Laminin
Nervous System
Axons
Aorta
Retina
Ligands

Keywords

  • Cell surface receptors
  • Extracellular matrix
  • Myoblasts
  • Nervous system

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology

Cite this

Bronner-Fraser, M., Artinger, M., Muschler, J., & Horwitz, A. F. (1992). Developmentally regulated expression of α6 integrin in avian embryos. Development, 115(1), 197-211.

Developmentally regulated expression of α6 integrin in avian embryos. / Bronner-Fraser, Marianne; Artinger, Michael; Muschler, John; Horwitz, Alan F.

In: Development, Vol. 115, No. 1, 05.1992, p. 197-211.

Research output: Contribution to journalArticle

Bronner-Fraser, M, Artinger, M, Muschler, J & Horwitz, AF 1992, 'Developmentally regulated expression of α6 integrin in avian embryos', Development, vol. 115, no. 1, pp. 197-211.
Bronner-Fraser M, Artinger M, Muschler J, Horwitz AF. Developmentally regulated expression of α6 integrin in avian embryos. Development. 1992 May;115(1):197-211.
Bronner-Fraser, Marianne ; Artinger, Michael ; Muschler, John ; Horwitz, Alan F. / Developmentally regulated expression of α6 integrin in avian embryos. In: Development. 1992 ; Vol. 115, No. 1. pp. 197-211.
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