Developmental Switch in Neuropeptide Y and Melanocortin Effects in the Paraventricular Nucleus of the Hypothalamus

Igor Melnick, Nina Pronchuk, Michael A. Cowley, Kevin L. Grove, William F. Colmers

    Research output: Contribution to journalArticle

    61 Scopus citations

    Abstract

    Homeostatic regulation of energy balance in rodents changes dramatically during the first 3 postnatal weeks. Neuropeptide Y (NPY) and melanocortin neurons in the arcuate nucleus, a primary energy homeostatic center in adults, do not fully innervate the paraventricular nucleus (PVN) until the third postnatal week. We have identified two classes of PVN neurons responsive to these neuropeptides, tonically firing neurosecretory (NS) and burst-firing preautonomic (PA) cells. In neonates, NPY could inhibit GABAergic inputs to nearly all NS and PA neurons, while melanocortin regulation was minimal. However, there was a dramatic, age-dependent decrease in NPY responses specifically in the PA neurons, and a 3-fold increase in melanocortin responses in NS cells. These age-dependent changes were accompanied by changes in spontaneous GABAergic currents onto these neurons. This primarily NPYergic regulation in the neonates likely promotes the positive energy balance necessary for growth, while the developmental switch correlates with maturation of homeostatic regulation of energy balance.

    Original languageEnglish (US)
    Pages (from-to)1103-1115
    Number of pages13
    JournalNeuron
    Volume56
    Issue number6
    DOIs
    StatePublished - Dec 20 2007

    ASJC Scopus subject areas

    • Neuroscience(all)

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