TY - JOUR
T1 - Developmental outcomes of children with congenital diaphragmatic hernia
T2 - A multicenter prospective study
AU - Wynn, Julia
AU - Aspelund, Gudrun
AU - Zygmunt, Annette
AU - Stolar, Charles J.H.
AU - Mychaliska, George
AU - Butcher, Jennifer
AU - Lim, Foong Yen
AU - Gratton, Teresa
AU - Potoka, Douglas
AU - Brennan, Kate
AU - Azarow, Ken
AU - Jackson, Barbara
AU - Needelman, Howard
AU - Crombleholme, Timothy
AU - Zhang, Yuan
AU - Duong, Jimmy
AU - Arkovitz, Marc S.
AU - Chung, Wendy K.
AU - Farkouh, Christiana
N1 - Funding Information:
Funding: This work was supported by NIH grant HD057036 . The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
PY - 2013/10
Y1 - 2013/10
N2 - Purpose To determine developmental outcomes and associated factors in patients with congenital diaphragmatic hernia (CDH) at 2 years of age. Methods This is a multicenter prospective study of a CDH birth cohort. Clinical and socioeconomic data were collected. Bayley Scales of Infant Development (BSID-III) and Vineland Adaptive Behavior Scales (VABS-II) were performed at 2 years of age. Results BSID-III and VABS-II assessments were completed on 48 and 49 children, respectively. The BSID-III mean cognitive, language, and motor scores were significantly below the norm mean with average scores of 93 ± 15, 95 ± 16, and 95 ± 11. Ten percent (5/47) scored more than 2 standard deviations below the norm on one or more domains. VABS-II scores were similar to BSID-III scores with mean communication, daily living skills, social, motor, adaptive behavior scores of 97 ± 14, 94 ± 16, 93 ± 13, 97 ± 10, and 94 ± 14. For the BSID-III, supplemental oxygen at 28 days, a prenatal diagnosis, need for extracorporeal membrane oxygenation (ECMO) and exclusive tube feeds at time of discharge were associated with lower scores. At 2 years of age, history of hospital readmission and need for tube feeds were associated with lower scores. Lower socioeconomic status correlated with lower developmental scores when adjusted for significant health factors. Conclusion CDH patients on average have lower developmental scores at 2 years of age compared to the norm. A need for ECMO, oxygen at 28 days of life, ongoing health issues and lower socioeconomic status are factors associated with developmental delays.
AB - Purpose To determine developmental outcomes and associated factors in patients with congenital diaphragmatic hernia (CDH) at 2 years of age. Methods This is a multicenter prospective study of a CDH birth cohort. Clinical and socioeconomic data were collected. Bayley Scales of Infant Development (BSID-III) and Vineland Adaptive Behavior Scales (VABS-II) were performed at 2 years of age. Results BSID-III and VABS-II assessments were completed on 48 and 49 children, respectively. The BSID-III mean cognitive, language, and motor scores were significantly below the norm mean with average scores of 93 ± 15, 95 ± 16, and 95 ± 11. Ten percent (5/47) scored more than 2 standard deviations below the norm on one or more domains. VABS-II scores were similar to BSID-III scores with mean communication, daily living skills, social, motor, adaptive behavior scores of 97 ± 14, 94 ± 16, 93 ± 13, 97 ± 10, and 94 ± 14. For the BSID-III, supplemental oxygen at 28 days, a prenatal diagnosis, need for extracorporeal membrane oxygenation (ECMO) and exclusive tube feeds at time of discharge were associated with lower scores. At 2 years of age, history of hospital readmission and need for tube feeds were associated with lower scores. Lower socioeconomic status correlated with lower developmental scores when adjusted for significant health factors. Conclusion CDH patients on average have lower developmental scores at 2 years of age compared to the norm. A need for ECMO, oxygen at 28 days of life, ongoing health issues and lower socioeconomic status are factors associated with developmental delays.
KW - Congenital diaphragmatic hernia
KW - Hollingshead
KW - Neurodevelopment
KW - Socioeconomic status
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U2 - 10.1016/j.jpedsurg.2013.02.041
DO - 10.1016/j.jpedsurg.2013.02.041
M3 - Article
C2 - 24094947
AN - SCOPUS:84885167689
SN - 0022-3468
VL - 48
SP - 1995
EP - 2004
JO - Journal of Pediatric Surgery
JF - Journal of Pediatric Surgery
IS - 10
ER -