Developmental outcomes of children with congenital diaphragmatic hernia

A multicenter prospective study

Julia Wynn, Gudrun Aspelund, Annette Zygmunt, Charles J H Stolar, George Mychaliska, Jennifer Butcher, Foong Yen Lim, Teresa Gratton, Douglas Potoka, Kate Brennan, Kenneth Azarow, Barbara Jackson, Howard Needelman, Timothy Crombleholme, Yuan Zhang, Jimmy Duong, Marc S. Arkovitz, Wendy K. Chung, Christiana Farkouh

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Purpose To determine developmental outcomes and associated factors in patients with congenital diaphragmatic hernia (CDH) at 2 years of age. Methods This is a multicenter prospective study of a CDH birth cohort. Clinical and socioeconomic data were collected. Bayley Scales of Infant Development (BSID-III) and Vineland Adaptive Behavior Scales (VABS-II) were performed at 2 years of age. Results BSID-III and VABS-II assessments were completed on 48 and 49 children, respectively. The BSID-III mean cognitive, language, and motor scores were significantly below the norm mean with average scores of 93 ± 15, 95 ± 16, and 95 ± 11. Ten percent (5/47) scored more than 2 standard deviations below the norm on one or more domains. VABS-II scores were similar to BSID-III scores with mean communication, daily living skills, social, motor, adaptive behavior scores of 97 ± 14, 94 ± 16, 93 ± 13, 97 ± 10, and 94 ± 14. For the BSID-III, supplemental oxygen at 28 days, a prenatal diagnosis, need for extracorporeal membrane oxygenation (ECMO) and exclusive tube feeds at time of discharge were associated with lower scores. At 2 years of age, history of hospital readmission and need for tube feeds were associated with lower scores. Lower socioeconomic status correlated with lower developmental scores when adjusted for significant health factors. Conclusion CDH patients on average have lower developmental scores at 2 years of age compared to the norm. A need for ECMO, oxygen at 28 days of life, ongoing health issues and lower socioeconomic status are factors associated with developmental delays.

Original languageEnglish (US)
Pages (from-to)1995-2004
Number of pages10
JournalJournal of Pediatric Surgery
Volume48
Issue number10
DOIs
StatePublished - Oct 2013
Externally publishedYes

Fingerprint

Multicenter Studies
Extracorporeal Membrane Oxygenation
Psychological Adaptation
Prospective Studies
Social Class
Oxygen
Patient Readmission
Motor Skills
Health
Child Development
Prenatal Diagnosis
Language
Communication
Parturition
Congenital Diaphragmatic Hernias
Diaphragmatic Hernia 2

Keywords

  • Congenital diaphragmatic hernia
  • Hollingshead
  • Neurodevelopment
  • Socioeconomic status

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health

Cite this

Wynn, J., Aspelund, G., Zygmunt, A., Stolar, C. J. H., Mychaliska, G., Butcher, J., ... Farkouh, C. (2013). Developmental outcomes of children with congenital diaphragmatic hernia: A multicenter prospective study. Journal of Pediatric Surgery, 48(10), 1995-2004. https://doi.org/10.1016/j.jpedsurg.2013.02.041

Developmental outcomes of children with congenital diaphragmatic hernia : A multicenter prospective study. / Wynn, Julia; Aspelund, Gudrun; Zygmunt, Annette; Stolar, Charles J H; Mychaliska, George; Butcher, Jennifer; Lim, Foong Yen; Gratton, Teresa; Potoka, Douglas; Brennan, Kate; Azarow, Kenneth; Jackson, Barbara; Needelman, Howard; Crombleholme, Timothy; Zhang, Yuan; Duong, Jimmy; Arkovitz, Marc S.; Chung, Wendy K.; Farkouh, Christiana.

In: Journal of Pediatric Surgery, Vol. 48, No. 10, 10.2013, p. 1995-2004.

Research output: Contribution to journalArticle

Wynn, J, Aspelund, G, Zygmunt, A, Stolar, CJH, Mychaliska, G, Butcher, J, Lim, FY, Gratton, T, Potoka, D, Brennan, K, Azarow, K, Jackson, B, Needelman, H, Crombleholme, T, Zhang, Y, Duong, J, Arkovitz, MS, Chung, WK & Farkouh, C 2013, 'Developmental outcomes of children with congenital diaphragmatic hernia: A multicenter prospective study', Journal of Pediatric Surgery, vol. 48, no. 10, pp. 1995-2004. https://doi.org/10.1016/j.jpedsurg.2013.02.041
Wynn, Julia ; Aspelund, Gudrun ; Zygmunt, Annette ; Stolar, Charles J H ; Mychaliska, George ; Butcher, Jennifer ; Lim, Foong Yen ; Gratton, Teresa ; Potoka, Douglas ; Brennan, Kate ; Azarow, Kenneth ; Jackson, Barbara ; Needelman, Howard ; Crombleholme, Timothy ; Zhang, Yuan ; Duong, Jimmy ; Arkovitz, Marc S. ; Chung, Wendy K. ; Farkouh, Christiana. / Developmental outcomes of children with congenital diaphragmatic hernia : A multicenter prospective study. In: Journal of Pediatric Surgery. 2013 ; Vol. 48, No. 10. pp. 1995-2004.
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abstract = "Purpose To determine developmental outcomes and associated factors in patients with congenital diaphragmatic hernia (CDH) at 2 years of age. Methods This is a multicenter prospective study of a CDH birth cohort. Clinical and socioeconomic data were collected. Bayley Scales of Infant Development (BSID-III) and Vineland Adaptive Behavior Scales (VABS-II) were performed at 2 years of age. Results BSID-III and VABS-II assessments were completed on 48 and 49 children, respectively. The BSID-III mean cognitive, language, and motor scores were significantly below the norm mean with average scores of 93 ± 15, 95 ± 16, and 95 ± 11. Ten percent (5/47) scored more than 2 standard deviations below the norm on one or more domains. VABS-II scores were similar to BSID-III scores with mean communication, daily living skills, social, motor, adaptive behavior scores of 97 ± 14, 94 ± 16, 93 ± 13, 97 ± 10, and 94 ± 14. For the BSID-III, supplemental oxygen at 28 days, a prenatal diagnosis, need for extracorporeal membrane oxygenation (ECMO) and exclusive tube feeds at time of discharge were associated with lower scores. At 2 years of age, history of hospital readmission and need for tube feeds were associated with lower scores. Lower socioeconomic status correlated with lower developmental scores when adjusted for significant health factors. Conclusion CDH patients on average have lower developmental scores at 2 years of age compared to the norm. A need for ECMO, oxygen at 28 days of life, ongoing health issues and lower socioeconomic status are factors associated with developmental delays.",
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AU - Aspelund, Gudrun

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AU - Stolar, Charles J H

AU - Mychaliska, George

AU - Butcher, Jennifer

AU - Lim, Foong Yen

AU - Gratton, Teresa

AU - Potoka, Douglas

AU - Brennan, Kate

AU - Azarow, Kenneth

AU - Jackson, Barbara

AU - Needelman, Howard

AU - Crombleholme, Timothy

AU - Zhang, Yuan

AU - Duong, Jimmy

AU - Arkovitz, Marc S.

AU - Chung, Wendy K.

AU - Farkouh, Christiana

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N2 - Purpose To determine developmental outcomes and associated factors in patients with congenital diaphragmatic hernia (CDH) at 2 years of age. Methods This is a multicenter prospective study of a CDH birth cohort. Clinical and socioeconomic data were collected. Bayley Scales of Infant Development (BSID-III) and Vineland Adaptive Behavior Scales (VABS-II) were performed at 2 years of age. Results BSID-III and VABS-II assessments were completed on 48 and 49 children, respectively. The BSID-III mean cognitive, language, and motor scores were significantly below the norm mean with average scores of 93 ± 15, 95 ± 16, and 95 ± 11. Ten percent (5/47) scored more than 2 standard deviations below the norm on one or more domains. VABS-II scores were similar to BSID-III scores with mean communication, daily living skills, social, motor, adaptive behavior scores of 97 ± 14, 94 ± 16, 93 ± 13, 97 ± 10, and 94 ± 14. For the BSID-III, supplemental oxygen at 28 days, a prenatal diagnosis, need for extracorporeal membrane oxygenation (ECMO) and exclusive tube feeds at time of discharge were associated with lower scores. At 2 years of age, history of hospital readmission and need for tube feeds were associated with lower scores. Lower socioeconomic status correlated with lower developmental scores when adjusted for significant health factors. Conclusion CDH patients on average have lower developmental scores at 2 years of age compared to the norm. A need for ECMO, oxygen at 28 days of life, ongoing health issues and lower socioeconomic status are factors associated with developmental delays.

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KW - Congenital diaphragmatic hernia

KW - Hollingshead

KW - Neurodevelopment

KW - Socioeconomic status

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