Developmental Neurotoxicity: An Update

Philipp J. Houck, Ansgar Brambrink, Jennifer Waspe, James D. O'Leary, Riva Ko

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


In the section of "Developmental Neurotoxicity: An Update" of the Pediatric Anesthesia Neurodevelopmental Assessment (PANDA) symposium 2018 the speakers presented the current literature in translational and clinical research. Dr. Brambrink spoke about translational research in anesthetic neurotoxicity, beginning with discovery in the rodent model, then focusing on evidence from nonhuman primates. Dr. Waspe applied the methodology of Adverse Outcome Pathways from the field of toxicology to developmental neurotoxicity of anesthetics. Dr. O'Leary presented relevant clinical studies that were published in 2017 divided by a focus on academic performance, clinical outcomes or diagnoses, or neuropsychological testing.

Original languageEnglish (US)
Pages (from-to)108-114
Number of pages7
JournalJournal of Neurosurgical Anesthesiology
Issue number1
StatePublished - Jan 1 2019
Externally publishedYes


  • biomarkers
  • clinical outcomes
  • clinical research
  • developmental neurotoxicity
  • pathway
  • translational research

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology
  • Anesthesiology and Pain Medicine


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