Developmental expression of the rat somatostatin gene

H. H. Zingg, Richard Goodman, J. F. Habener

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

The developmental expression of the somatostatin (SRIF) gene was investigated in rat brain and stomach, two SRIF-rich tissues. The accumulation of mRNA encoding SRIF was determined in these organs during fetal and early (1-4 weeks) postnatal development using a sensitive radiodensitometric cDNA hybridization assay and a cloned preprosomatostatin cDNA. A single band of mRNA which hybridized specifically to the rat SRIF cDNA was detected in both tissues examined throughout ontogenesis, suggesting that the same SRIF gene is expressed in these tissues in the developing as well as in the adult rat. Whereas SRIF mRNA was undetectable in fetal stomach and rose gradually only after birth, brain SRIF mRNA was already detectable by day 7 of embryonic life and reached concentrations corresponding to those in the adult brain by embryonic day 20. These marked differences may reflect basic differences in the developmental regulation of SRIF gene expression in neural vs. nonneural tissues or may be related to the onset of functional activity in the organs studied.

Original languageEnglish (US)
Pages (from-to)90-94
Number of pages5
JournalEndocrinology
Volume115
Issue number1
StatePublished - 1984
Externally publishedYes

Fingerprint

Somatostatin
Messenger RNA
Complementary DNA
Genes
Developmental Gene Expression Regulation
Stomach
Brain
Parturition

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Zingg, H. H., Goodman, R., & Habener, J. F. (1984). Developmental expression of the rat somatostatin gene. Endocrinology, 115(1), 90-94.

Developmental expression of the rat somatostatin gene. / Zingg, H. H.; Goodman, Richard; Habener, J. F.

In: Endocrinology, Vol. 115, No. 1, 1984, p. 90-94.

Research output: Contribution to journalArticle

Zingg, HH, Goodman, R & Habener, JF 1984, 'Developmental expression of the rat somatostatin gene', Endocrinology, vol. 115, no. 1, pp. 90-94.
Zingg, H. H. ; Goodman, Richard ; Habener, J. F. / Developmental expression of the rat somatostatin gene. In: Endocrinology. 1984 ; Vol. 115, No. 1. pp. 90-94.
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