Developmental expression of insulin-like growth factor-II receptor immunoreactivity in the rat central nervous system

K. L. Valentino, I. Ocrant, Ronald (Ron) Rosenfeld

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

A polyclonal antiserum raised against the insulin-like growth factor-II (IGF-II) receptor has been used to map the distribution of this receptor in the developing rat central nervous system (CNS). Transiently high levels of receptor immunoreactivity were found in the developing brain, particularly in the cortex and hypothalamus. The amount of receptor immunostaining in these areas decreases toward the time of birth, and levels are approximately equivalent to those in the adult by postnatal day 7. The choroid plexus, cerebral vasculature, ependymal cells, retina, and pituitary contain high levels of receptor immunoreactivity throughout embryogenesis and adulthood. Some mesodermally derived tissues, such as bone, also demonstrate transient expression of IGF-II receptor during fetal development. These data are consistent with potential roles for IGF-II in CNS development, in the development of specific mesodermal tissues, and in specific regions of the postnatal CNS.

Original languageEnglish (US)
Pages (from-to)914-920
Number of pages7
JournalEndocrinology
Volume126
Issue number2
StatePublished - Feb 1990
Externally publishedYes

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IGF Type 2 Receptor
Central Nervous System
Choroid Plexus
Insulin-Like Growth Factor II
Fetal Development
Hypothalamus
Embryonic Development
Retina
Immune Sera
Parturition
Bone and Bones
Brain

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Developmental expression of insulin-like growth factor-II receptor immunoreactivity in the rat central nervous system. / Valentino, K. L.; Ocrant, I.; Rosenfeld, Ronald (Ron).

In: Endocrinology, Vol. 126, No. 2, 02.1990, p. 914-920.

Research output: Contribution to journalArticle

Valentino, K. L. ; Ocrant, I. ; Rosenfeld, Ronald (Ron). / Developmental expression of insulin-like growth factor-II receptor immunoreactivity in the rat central nervous system. In: Endocrinology. 1990 ; Vol. 126, No. 2. pp. 914-920.
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