Developmental defects in mice and rats treated postnatally with cytosine arabinoside

Dean H. Percy, Daniel Albert

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

ICR Swiss albino mice and Sprague-Dawley rats were given cytosine arabinoside parenterally beginning at 1, 5, or 10 days of age. Animals were treated for 5 consecutive days at dosages ranging from 3.125 to 50 mg/kg/day. Numerous deaths and retardation of growth occurred in both species treated at higher dosages beginning at 1 day of age. Animals were examined histologically at 20 days of age. Cerebellar hypoplasia was especially marked in mice and rats treated beginning at 1 day of age. There was reduction in size of the cerebellum, with poorly delineated molecular, Purkinje cell, and internal granular layers. Retinal lesions were observed in both species, but were considerably more extensive in rats treated with cytosine arabinoside than in mice. Numerous rosettes were observed in the peripheral retina, with relative sparing of the central regions. Focal renal cortical dysplasia was also observed in animals treated beginning at 1 day of age. Autoradiographic studies indicated that significant cellular division occurs in the retina and renal cortex postnatally in both species. The significance of these studies with regard to the use of cytosine arabinoside in viral chemotherapy in newborn infants are yet to be determined.

Original languageEnglish (US)
Pages (from-to)381-397
Number of pages17
JournalExperimental and Molecular Pathology
Volume21
Issue number3
DOIs
StatePublished - Jan 1 1974
Externally publishedYes

Fingerprint

Cytarabine
Rats
Animals
Defects
Retina
Kidney
Malformations of Cortical Development
Chemotherapy
Purkinje Cells
Cerebellum
Sprague Dawley Rats
Newborn Infant
Drug Therapy
Growth

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Molecular Biology
  • Pathology and Forensic Medicine

Cite this

Developmental defects in mice and rats treated postnatally with cytosine arabinoside. / Percy, Dean H.; Albert, Daniel.

In: Experimental and Molecular Pathology, Vol. 21, No. 3, 01.01.1974, p. 381-397.

Research output: Contribution to journalArticle

@article{ccb9f961bca246598372a7cb24fd0159,
title = "Developmental defects in mice and rats treated postnatally with cytosine arabinoside",
abstract = "ICR Swiss albino mice and Sprague-Dawley rats were given cytosine arabinoside parenterally beginning at 1, 5, or 10 days of age. Animals were treated for 5 consecutive days at dosages ranging from 3.125 to 50 mg/kg/day. Numerous deaths and retardation of growth occurred in both species treated at higher dosages beginning at 1 day of age. Animals were examined histologically at 20 days of age. Cerebellar hypoplasia was especially marked in mice and rats treated beginning at 1 day of age. There was reduction in size of the cerebellum, with poorly delineated molecular, Purkinje cell, and internal granular layers. Retinal lesions were observed in both species, but were considerably more extensive in rats treated with cytosine arabinoside than in mice. Numerous rosettes were observed in the peripheral retina, with relative sparing of the central regions. Focal renal cortical dysplasia was also observed in animals treated beginning at 1 day of age. Autoradiographic studies indicated that significant cellular division occurs in the retina and renal cortex postnatally in both species. The significance of these studies with regard to the use of cytosine arabinoside in viral chemotherapy in newborn infants are yet to be determined.",
author = "Percy, {Dean H.} and Daniel Albert",
year = "1974",
month = "1",
day = "1",
doi = "10.1016/0014-4800(74)90104-X",
language = "English (US)",
volume = "21",
pages = "381--397",
journal = "Experimental and Molecular Pathology",
issn = "0014-4800",
publisher = "Academic Press Inc.",
number = "3",

}

TY - JOUR

T1 - Developmental defects in mice and rats treated postnatally with cytosine arabinoside

AU - Percy, Dean H.

AU - Albert, Daniel

PY - 1974/1/1

Y1 - 1974/1/1

N2 - ICR Swiss albino mice and Sprague-Dawley rats were given cytosine arabinoside parenterally beginning at 1, 5, or 10 days of age. Animals were treated for 5 consecutive days at dosages ranging from 3.125 to 50 mg/kg/day. Numerous deaths and retardation of growth occurred in both species treated at higher dosages beginning at 1 day of age. Animals were examined histologically at 20 days of age. Cerebellar hypoplasia was especially marked in mice and rats treated beginning at 1 day of age. There was reduction in size of the cerebellum, with poorly delineated molecular, Purkinje cell, and internal granular layers. Retinal lesions were observed in both species, but were considerably more extensive in rats treated with cytosine arabinoside than in mice. Numerous rosettes were observed in the peripheral retina, with relative sparing of the central regions. Focal renal cortical dysplasia was also observed in animals treated beginning at 1 day of age. Autoradiographic studies indicated that significant cellular division occurs in the retina and renal cortex postnatally in both species. The significance of these studies with regard to the use of cytosine arabinoside in viral chemotherapy in newborn infants are yet to be determined.

AB - ICR Swiss albino mice and Sprague-Dawley rats were given cytosine arabinoside parenterally beginning at 1, 5, or 10 days of age. Animals were treated for 5 consecutive days at dosages ranging from 3.125 to 50 mg/kg/day. Numerous deaths and retardation of growth occurred in both species treated at higher dosages beginning at 1 day of age. Animals were examined histologically at 20 days of age. Cerebellar hypoplasia was especially marked in mice and rats treated beginning at 1 day of age. There was reduction in size of the cerebellum, with poorly delineated molecular, Purkinje cell, and internal granular layers. Retinal lesions were observed in both species, but were considerably more extensive in rats treated with cytosine arabinoside than in mice. Numerous rosettes were observed in the peripheral retina, with relative sparing of the central regions. Focal renal cortical dysplasia was also observed in animals treated beginning at 1 day of age. Autoradiographic studies indicated that significant cellular division occurs in the retina and renal cortex postnatally in both species. The significance of these studies with regard to the use of cytosine arabinoside in viral chemotherapy in newborn infants are yet to be determined.

UR - http://www.scopus.com/inward/record.url?scp=0016293811&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016293811&partnerID=8YFLogxK

U2 - 10.1016/0014-4800(74)90104-X

DO - 10.1016/0014-4800(74)90104-X

M3 - Article

C2 - 4430346

AN - SCOPUS:0016293811

VL - 21

SP - 381

EP - 397

JO - Experimental and Molecular Pathology

JF - Experimental and Molecular Pathology

SN - 0014-4800

IS - 3

ER -