Developmental changes in the fatty acids of synaptic membrane phospholipids

Effect of protein malnutrition

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The acyl-linked fatty acid composition of the major phospholipid species in rat cortical synaptic membranes was determined at various stages of development. For most species there was a decrease during development in the short chain saturated fatty acids, 14:0 and 16:0, an increase in 18:0 and 22:6 (n-3) and an increase in the ratio of 22:6 (n-3)/22:5 (n-6). Pups were protein deprived by feeding the dams a 12% casein diet as compared to the 24% casein control diet. Protein malnutrition markedly affected the composition of acyl-linked fatty acids in the synaptic membranes. The increases in the ratio of 22:6 (n-3)/22:5 (n-6) fatty acids were especially compromised.

Original languageEnglish (US)
Pages (from-to)935-947
Number of pages13
JournalNeurochemical Research
Volume6
Issue number9
DOIs
StatePublished - Sep 1981
Externally publishedYes

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Synaptic Membranes
Malnutrition
Phospholipids
Fatty Acids
Membranes
Nutrition
Caseins
Proteins
Diet
Volatile Fatty Acids
Chemical analysis
Dams
Rats

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry

Cite this

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title = "Developmental changes in the fatty acids of synaptic membrane phospholipids: Effect of protein malnutrition",
abstract = "The acyl-linked fatty acid composition of the major phospholipid species in rat cortical synaptic membranes was determined at various stages of development. For most species there was a decrease during development in the short chain saturated fatty acids, 14:0 and 16:0, an increase in 18:0 and 22:6 (n-3) and an increase in the ratio of 22:6 (n-3)/22:5 (n-6). Pups were protein deprived by feeding the dams a 12{\%} casein diet as compared to the 24{\%} casein control diet. Protein malnutrition markedly affected the composition of acyl-linked fatty acids in the synaptic membranes. The increases in the ratio of 22:6 (n-3)/22:5 (n-6) fatty acids were especially compromised.",
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AB - The acyl-linked fatty acid composition of the major phospholipid species in rat cortical synaptic membranes was determined at various stages of development. For most species there was a decrease during development in the short chain saturated fatty acids, 14:0 and 16:0, an increase in 18:0 and 22:6 (n-3) and an increase in the ratio of 22:6 (n-3)/22:5 (n-6). Pups were protein deprived by feeding the dams a 12% casein diet as compared to the 24% casein control diet. Protein malnutrition markedly affected the composition of acyl-linked fatty acids in the synaptic membranes. The increases in the ratio of 22:6 (n-3)/22:5 (n-6) fatty acids were especially compromised.

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