Developmental changes in the fatty acids of synaptic membrane phospholipids: Effect of protein malnutrition

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The acyl-linked fatty acid composition of the major phospholipid species in rat cortical synaptic membranes was determined at various stages of development. For most species there was a decrease during development in the short chain saturated fatty acids, 14:0 and 16:0, an increase in 18:0 and 22:6 (n-3) and an increase in the ratio of 22:6 (n-3)/22:5 (n-6). Pups were protein deprived by feeding the dams a 12% casein diet as compared to the 24% casein control diet. Protein malnutrition markedly affected the composition of acyl-linked fatty acids in the synaptic membranes. The increases in the ratio of 22:6 (n-3)/22:5 (n-6) fatty acids were especially compromised.

Original languageEnglish (US)
Pages (from-to)935-947
Number of pages13
JournalNeurochemical Research
Issue number9
StatePublished - Sep 1 1981


ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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