Developmental and postdevelopmental uptake of dietary organic and inorganic selenium into the molar teeth of rats

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The mechanism for the uptake of dietary inorganic and organic selenium by the fully developed, mature molar teeth of mother rats and the developing molar teeth of their pups was studied. Pregnant rats received drinking solutions containing either 0.2 ppm selenomethionine plus 0.045 μCi 75Se selenomethionine per ml or 0.2 ppm Na2SeO3 plus 0.043 μCi Na2 75SeO3 per ml from day 10 of pregnancy until parturition. 13 Days postpartum, the uptake of dietary 75Se into developing molar teeth was more extensive than the postdevelopmental uptake onto mature teeth. Developing molar teeth incorporated more 75Se from dietary selenomethionine than from selenite, as did many hard and soft tissues studied. The major portion of 75Se in enamel and dentine was located in the protein fraction of these dental tissues. Dialysis experiments showed that the selenium in enamel and dentine existed in at least 3 forms: loosely bound selenium, proteinaceous selenotrisulfides and proteinaceous stable selenium. These data and the results of a previous study provide evidence that selenium incorporated into developing proteins as selenotrisulfides or selenoamino acids may be responsible for the increases in dental caries reported in man and experimental animals ingesting somewhat increased amounts of dietary selenium.

Original languageEnglish (US)
Pages (from-to)338-347
Number of pages10
JournalJournal of Nutrition
Volume105
Issue number3
StatePublished - 1975

Fingerprint

Selenium
selenium
Tooth
teeth
Selenomethionine
uptake mechanisms
rats
selenomethionine
Dentin
Dental Enamel
tooth enamel
seleno amino acids
Selenious Acid
Dental Caries
dental caries
Postpartum Period
selenites
Drinking
Dialysis
Proteins

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

Cite this

@article{76e958f11d4148bfa823b351730762db,
title = "Developmental and postdevelopmental uptake of dietary organic and inorganic selenium into the molar teeth of rats",
abstract = "The mechanism for the uptake of dietary inorganic and organic selenium by the fully developed, mature molar teeth of mother rats and the developing molar teeth of their pups was studied. Pregnant rats received drinking solutions containing either 0.2 ppm selenomethionine plus 0.045 μCi 75Se selenomethionine per ml or 0.2 ppm Na2SeO3 plus 0.043 μCi Na2 75SeO3 per ml from day 10 of pregnancy until parturition. 13 Days postpartum, the uptake of dietary 75Se into developing molar teeth was more extensive than the postdevelopmental uptake onto mature teeth. Developing molar teeth incorporated more 75Se from dietary selenomethionine than from selenite, as did many hard and soft tissues studied. The major portion of 75Se in enamel and dentine was located in the protein fraction of these dental tissues. Dialysis experiments showed that the selenium in enamel and dentine existed in at least 3 forms: loosely bound selenium, proteinaceous selenotrisulfides and proteinaceous stable selenium. These data and the results of a previous study provide evidence that selenium incorporated into developing proteins as selenotrisulfides or selenoamino acids may be responsible for the increases in dental caries reported in man and experimental animals ingesting somewhat increased amounts of dietary selenium.",
author = "Shearer, {Thomas (Tom)}",
year = "1975",
language = "English (US)",
volume = "105",
pages = "338--347",
journal = "Journal of Nutrition",
issn = "0022-3166",
publisher = "American Society for Nutrition",
number = "3",

}

TY - JOUR

T1 - Developmental and postdevelopmental uptake of dietary organic and inorganic selenium into the molar teeth of rats

AU - Shearer, Thomas (Tom)

PY - 1975

Y1 - 1975

N2 - The mechanism for the uptake of dietary inorganic and organic selenium by the fully developed, mature molar teeth of mother rats and the developing molar teeth of their pups was studied. Pregnant rats received drinking solutions containing either 0.2 ppm selenomethionine plus 0.045 μCi 75Se selenomethionine per ml or 0.2 ppm Na2SeO3 plus 0.043 μCi Na2 75SeO3 per ml from day 10 of pregnancy until parturition. 13 Days postpartum, the uptake of dietary 75Se into developing molar teeth was more extensive than the postdevelopmental uptake onto mature teeth. Developing molar teeth incorporated more 75Se from dietary selenomethionine than from selenite, as did many hard and soft tissues studied. The major portion of 75Se in enamel and dentine was located in the protein fraction of these dental tissues. Dialysis experiments showed that the selenium in enamel and dentine existed in at least 3 forms: loosely bound selenium, proteinaceous selenotrisulfides and proteinaceous stable selenium. These data and the results of a previous study provide evidence that selenium incorporated into developing proteins as selenotrisulfides or selenoamino acids may be responsible for the increases in dental caries reported in man and experimental animals ingesting somewhat increased amounts of dietary selenium.

AB - The mechanism for the uptake of dietary inorganic and organic selenium by the fully developed, mature molar teeth of mother rats and the developing molar teeth of their pups was studied. Pregnant rats received drinking solutions containing either 0.2 ppm selenomethionine plus 0.045 μCi 75Se selenomethionine per ml or 0.2 ppm Na2SeO3 plus 0.043 μCi Na2 75SeO3 per ml from day 10 of pregnancy until parturition. 13 Days postpartum, the uptake of dietary 75Se into developing molar teeth was more extensive than the postdevelopmental uptake onto mature teeth. Developing molar teeth incorporated more 75Se from dietary selenomethionine than from selenite, as did many hard and soft tissues studied. The major portion of 75Se in enamel and dentine was located in the protein fraction of these dental tissues. Dialysis experiments showed that the selenium in enamel and dentine existed in at least 3 forms: loosely bound selenium, proteinaceous selenotrisulfides and proteinaceous stable selenium. These data and the results of a previous study provide evidence that selenium incorporated into developing proteins as selenotrisulfides or selenoamino acids may be responsible for the increases in dental caries reported in man and experimental animals ingesting somewhat increased amounts of dietary selenium.

UR - http://www.scopus.com/inward/record.url?scp=0016662615&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016662615&partnerID=8YFLogxK

M3 - Article

VL - 105

SP - 338

EP - 347

JO - Journal of Nutrition

JF - Journal of Nutrition

SN - 0022-3166

IS - 3

ER -