Development of the neuromuscular junction: Genetic analysis in mice

Joshua R. Sanes, Elizabeth D. Apel, Robert W. Burgess, Ronald B. Emerson, Guoping Feng, Medha Gautam, David Glass, R. Mark Grady, Eric Krejci, Jeff W. Lichtman, Jonathan T. Lu, Jean Massoulié, Jeffrey H. Miner, Lisa M. Moscoso, Quyen Nguyen, Mia Nichol, Peter G. Noakes, Bruce Patton, Young Jin Son, George D. YancopoulosHeather Zhou

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Formation of the skeletal neuromuscular junction is a multi-step process that requires communication between the nerve and muscle. Studies in many laboratories have led to identification of factors that seem likely to mediate these interactions. 'Knock-out' mice have now been generated with mutations in several genes that encode candidate transsynaptic messengers and components of their effector mechanisms. Using these mice, it is possible to test hypotheses about the control of synaptogenesis. Here, we review our studies on neuromuscular development in mutant mice lacking agrin αCGRP, rapsyn, MuSK, dystrophin, dystrobrevin, utrophin, laminin ≱, laminin β2, collagen 3/4 (IV), the acetylcholine receptor ε subunit, the collagenous tail of acetylcholinesterase, fibroblast growth factor-5, the neural cell adhesion molecule, and tenascin-C.

Original languageEnglish (US)
Pages (from-to)167-172
Number of pages6
JournalJournal of Physiology Paris
Volume92
Issue number3-4
DOIs
StatePublished - Jun 1998
Externally publishedYes

Fingerprint

Neuromuscular Junction
Laminin
Fibroblast Growth Factor 5
Utrophin
Agrin
Tenascin
Neural Cell Adhesion Molecules
Dystrophin
Cholinergic Receptors
Acetylcholinesterase
Knockout Mice
Tail
Collagen
Communication
Muscles
Mutation
Genes
dystrobrevin
peripheral membrane protein 43K

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology (medical)

Cite this

Sanes, J. R., Apel, E. D., Burgess, R. W., Emerson, R. B., Feng, G., Gautam, M., ... Zhou, H. (1998). Development of the neuromuscular junction: Genetic analysis in mice. Journal of Physiology Paris, 92(3-4), 167-172. https://doi.org/10.1016/S0928-4257(98)80004-1

Development of the neuromuscular junction : Genetic analysis in mice. / Sanes, Joshua R.; Apel, Elizabeth D.; Burgess, Robert W.; Emerson, Ronald B.; Feng, Guoping; Gautam, Medha; Glass, David; Grady, R. Mark; Krejci, Eric; Lichtman, Jeff W.; Lu, Jonathan T.; Massoulié, Jean; Miner, Jeffrey H.; Moscoso, Lisa M.; Nguyen, Quyen; Nichol, Mia; Noakes, Peter G.; Patton, Bruce; Son, Young Jin; Yancopoulos, George D.; Zhou, Heather.

In: Journal of Physiology Paris, Vol. 92, No. 3-4, 06.1998, p. 167-172.

Research output: Contribution to journalArticle

Sanes, JR, Apel, ED, Burgess, RW, Emerson, RB, Feng, G, Gautam, M, Glass, D, Grady, RM, Krejci, E, Lichtman, JW, Lu, JT, Massoulié, J, Miner, JH, Moscoso, LM, Nguyen, Q, Nichol, M, Noakes, PG, Patton, B, Son, YJ, Yancopoulos, GD & Zhou, H 1998, 'Development of the neuromuscular junction: Genetic analysis in mice', Journal of Physiology Paris, vol. 92, no. 3-4, pp. 167-172. https://doi.org/10.1016/S0928-4257(98)80004-1
Sanes JR, Apel ED, Burgess RW, Emerson RB, Feng G, Gautam M et al. Development of the neuromuscular junction: Genetic analysis in mice. Journal of Physiology Paris. 1998 Jun;92(3-4):167-172. https://doi.org/10.1016/S0928-4257(98)80004-1
Sanes, Joshua R. ; Apel, Elizabeth D. ; Burgess, Robert W. ; Emerson, Ronald B. ; Feng, Guoping ; Gautam, Medha ; Glass, David ; Grady, R. Mark ; Krejci, Eric ; Lichtman, Jeff W. ; Lu, Jonathan T. ; Massoulié, Jean ; Miner, Jeffrey H. ; Moscoso, Lisa M. ; Nguyen, Quyen ; Nichol, Mia ; Noakes, Peter G. ; Patton, Bruce ; Son, Young Jin ; Yancopoulos, George D. ; Zhou, Heather. / Development of the neuromuscular junction : Genetic analysis in mice. In: Journal of Physiology Paris. 1998 ; Vol. 92, No. 3-4. pp. 167-172.
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