Development of STI571 and its use in chronic myelogenous leukemia and other malignancies

M. J. Mauro, M. E. O'Dwyer, B. J. Druker

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Chronic myelogenous leukemia (CML) is a clonal hematopoetic stem cell disorder characterized by the (9:22) translocation and resultant production of the constitutively activated Bcr-Abl tyrosine kinase. Characterized clinically by marked myeloid proliferation, it terminates invariably in an acute leukemia. Conventional therapeutic options include interferon-based regimens and stem cell transplantation, with stem cell transplantation being the only curative therapy. Through rational drug development, STI571, a Bcr-Abl tyrosine kinase inhibitor, has emerged as a paradigm for gene product targeted therapy, offering new hope for expanded treatment options for patients with CML.

Original languageEnglish (US)
Pages (from-to)536-541
Number of pages6
JournalOncology Spectrums
Volume2
Issue number8
StatePublished - Oct 9 2001

ASJC Scopus subject areas

  • Health Policy

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