DEVELOPMENT OF NICOTINIC ACETYLCHOLINE RECEPTOR FUNCTION.

R. Kullberg, J. L. Owens, Paul Brehm

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

The biophysical properties of acetylcholine receptor (AChR) channels were studied in vivo in developing myotomal muscle of the amphibian, Xenopus laevis. Single-channel recordings from nonjunctional membrane revealed a class of low-conductance (37 pS), long-open-time (2 to 3 msec) AChR channels which appeared on embryonic membrane within 21 hr. of fertilization. At 45 hr. of age, a second class of higher-conductance (57 pS), brief-open-time (0. 7 msec) channels began to be expressed and, over the course of four days, became the most frequently observed channel type on the nonjunctional membrane. Activity of this channel was also predominant at junctional regions of mature myotomal muscle.

Original languageEnglish (US)
Title of host publicationIEEE/Engineering in Medicine and Biology Society Annual Conference
PublisherIEEE
Pages948-950
Number of pages3
StatePublished - 1986
Externally publishedYes

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Membranes
Muscle

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Kullberg, R., Owens, J. L., & Brehm, P. (1986). DEVELOPMENT OF NICOTINIC ACETYLCHOLINE RECEPTOR FUNCTION. In IEEE/Engineering in Medicine and Biology Society Annual Conference (pp. 948-950). IEEE.

DEVELOPMENT OF NICOTINIC ACETYLCHOLINE RECEPTOR FUNCTION. / Kullberg, R.; Owens, J. L.; Brehm, Paul.

IEEE/Engineering in Medicine and Biology Society Annual Conference. IEEE, 1986. p. 948-950.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Kullberg, R, Owens, JL & Brehm, P 1986, DEVELOPMENT OF NICOTINIC ACETYLCHOLINE RECEPTOR FUNCTION. in IEEE/Engineering in Medicine and Biology Society Annual Conference. IEEE, pp. 948-950.
Kullberg R, Owens JL, Brehm P. DEVELOPMENT OF NICOTINIC ACETYLCHOLINE RECEPTOR FUNCTION. In IEEE/Engineering in Medicine and Biology Society Annual Conference. IEEE. 1986. p. 948-950
Kullberg, R. ; Owens, J. L. ; Brehm, Paul. / DEVELOPMENT OF NICOTINIC ACETYLCHOLINE RECEPTOR FUNCTION. IEEE/Engineering in Medicine and Biology Society Annual Conference. IEEE, 1986. pp. 948-950
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