Development of Lymphocytotoxic and Platelet Reactive Antibodies: A Prospective Study in Patients with Acute Leukaemia

Derwood H. Pamphilon; David H. Farrell; Craig Donaldson; Paul A. Raymond; Clare A. Brady; Benjamin A. Bradley

doi:10.1111/j.1423-0410.1989.tb00818.x

Development of Lymphocytotoxic and Platelet Reactive Antibodies: A Prospective Study in Patients with Acute Leukaemia

Derwood H. Pamphilon, David H. Farrell, Craig Donaldson, Paul A. Raymond, Clare A. Brady, Benjamin A. Bradley

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Abstract. Lymphocytotoxic (LCT) and platelet reactive (PR) antibody (Ab) responses were serially determined in 49 patients with acute leukaemia. LCTAb were found in 20 patients and occurred in 13 patients with acute myeloid leukaemia and 7 patients with acute lymphoblastic leukaemia. Four differing patterns of LCTAb responses could be defined. Thirteen of 22 subjects showed marked reduction or loss of LCTAb. Indirect platelet immunofluorescence, measured by flow cytometry, provided the most convenient means of detecting PRAb which were found in 11 subjects and generally showed moderate or weak reactivity.

Original language	English (US)
Pages (from-to)	177-181
Number of pages	5
Journal	Vox sanguinis
Volume	57
Issue number	3
DOIs	https://doi.org/10.1111/j.1423-0410.1989.tb00818.x
State	Published - Oct 1989
Externally published	Yes

ASJC Scopus subject areas

Hematology

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10.1111/j.1423-0410.1989.tb00818.x

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title = "Development of Lymphocytotoxic and Platelet Reactive Antibodies: A Prospective Study in Patients with Acute Leukaemia",

abstract = "Abstract. Lymphocytotoxic (LCT) and platelet reactive (PR) antibody (Ab) responses were serially determined in 49 patients with acute leukaemia. LCTAb were found in 20 patients and occurred in 13 patients with acute myeloid leukaemia and 7 patients with acute lymphoblastic leukaemia. Four differing patterns of LCTAb responses could be defined. Thirteen of 22 subjects showed marked reduction or loss of LCTAb. Indirect platelet immunofluorescence, measured by flow cytometry, provided the most convenient means of detecting PRAb which were found in 11 subjects and generally showed moderate or weak reactivity.",

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T1 - Development of Lymphocytotoxic and Platelet Reactive Antibodies

T2 - A Prospective Study in Patients with Acute Leukaemia

AU - Pamphilon, Derwood H.

AU - Farrell, David H.

AU - Donaldson, Craig

AU - Raymond, Paul A.

AU - Brady, Clare A.

AU - Bradley, Benjamin A.

PY - 1989/10

Y1 - 1989/10

N2 - Abstract. Lymphocytotoxic (LCT) and platelet reactive (PR) antibody (Ab) responses were serially determined in 49 patients with acute leukaemia. LCTAb were found in 20 patients and occurred in 13 patients with acute myeloid leukaemia and 7 patients with acute lymphoblastic leukaemia. Four differing patterns of LCTAb responses could be defined. Thirteen of 22 subjects showed marked reduction or loss of LCTAb. Indirect platelet immunofluorescence, measured by flow cytometry, provided the most convenient means of detecting PRAb which were found in 11 subjects and generally showed moderate or weak reactivity.

AB - Abstract. Lymphocytotoxic (LCT) and platelet reactive (PR) antibody (Ab) responses were serially determined in 49 patients with acute leukaemia. LCTAb were found in 20 patients and occurred in 13 patients with acute myeloid leukaemia and 7 patients with acute lymphoblastic leukaemia. Four differing patterns of LCTAb responses could be defined. Thirteen of 22 subjects showed marked reduction or loss of LCTAb. Indirect platelet immunofluorescence, measured by flow cytometry, provided the most convenient means of detecting PRAb which were found in 11 subjects and generally showed moderate or weak reactivity.

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Development of Lymphocytotoxic and Platelet Reactive Antibodies: A Prospective Study in Patients with Acute Leukaemia

Abstract

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