TY - JOUR
T1 - Development of an electrophysiology (EP)-enabled intracardiac ultrasound catheter integrated with NavX 3-dimensional electrofield mapping for guiding cardiac EP interventions
T2 - Experimental studies
AU - Xiao, Kui Li
AU - Pemberton, James
AU - Thomenius, Kai
AU - Dentinger, Aaron
AU - Lowe, Robert I.
AU - Ashraf, Muhammad
AU - Shung, K. Kirk
AU - Chia, Raymond
AU - Stephens, Douglas N.
AU - O'Donnell, Matthew
AU - Mahajan, Aman
AU - Balaji, Seshadri
AU - Shivkumar, Kalyanam
AU - Sahn, David J.
PY - 2007/11
Y1 - 2007/11
N2 - Objective. We have developed an integrated high-resolution intracardiac echocardiography (ICE) catheter for electrophysiology (EP) testing, which can be coregistered in 3-dimensional space with EP testing and ablation catheters using electrofield sensing. Methods. Twelve open-chest pigs (34-55 kg) and 3 closed-chest pigs were studied. After introduction from the jugular or femoral venous locations, the 9F side-looking, highly steerable (0°-180°), 64-element array catheters could be manipulated easily throughout the right side of the heart. Multisite cardiac pacing was performed for assessing left ventricular (LV) synchrony using tissue Doppler methods. Also, in the open-chest pigs, right atrial (RA) and right ventricular (RV) ablations were performed with a separate radio frequency catheter under fluoroscopic guidance and visualized with ICE to characterize the changes. In the 3 closed-chest pigs, electrofield NavX 3-dimensional coregistration (St Jude Medical Corp, Minneapolis, MN) allowed us to test whether this additional feature could shorten the time necessary to perform 4 targeted ablations in each animal while imaging the ablation catheter and the adjacent region by ICE. Results. Intracardiac anatomy, tricuspid, aortic, pulmonary, and mitral valve function, and pulmonary vein flow were all imaged reproducibly from scanning locations in the RA or RV in all animals, along with assessment of cardiac motion and the effects of multisite pacing. Three-dimensional electrofield displays detailed the spatial relationship between the ICE catheter and ablation catheters such that the time to visualize and ablate 4 sites in each of the 3 closed-chest animals was reduced. Conclusions. This new technology is a first step in the integration of ICE with EP procedures.
AB - Objective. We have developed an integrated high-resolution intracardiac echocardiography (ICE) catheter for electrophysiology (EP) testing, which can be coregistered in 3-dimensional space with EP testing and ablation catheters using electrofield sensing. Methods. Twelve open-chest pigs (34-55 kg) and 3 closed-chest pigs were studied. After introduction from the jugular or femoral venous locations, the 9F side-looking, highly steerable (0°-180°), 64-element array catheters could be manipulated easily throughout the right side of the heart. Multisite cardiac pacing was performed for assessing left ventricular (LV) synchrony using tissue Doppler methods. Also, in the open-chest pigs, right atrial (RA) and right ventricular (RV) ablations were performed with a separate radio frequency catheter under fluoroscopic guidance and visualized with ICE to characterize the changes. In the 3 closed-chest pigs, electrofield NavX 3-dimensional coregistration (St Jude Medical Corp, Minneapolis, MN) allowed us to test whether this additional feature could shorten the time necessary to perform 4 targeted ablations in each animal while imaging the ablation catheter and the adjacent region by ICE. Results. Intracardiac anatomy, tricuspid, aortic, pulmonary, and mitral valve function, and pulmonary vein flow were all imaged reproducibly from scanning locations in the RA or RV in all animals, along with assessment of cardiac motion and the effects of multisite pacing. Three-dimensional electrofield displays detailed the spatial relationship between the ICE catheter and ablation catheters such that the time to visualize and ablate 4 sites in each of the 3 closed-chest animals was reduced. Conclusions. This new technology is a first step in the integration of ICE with EP procedures.
KW - Improved resolution
KW - Integrated
KW - Intracardiac imaging
KW - Rhythm analysis
KW - Steerability
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U2 - 10.7863/jum.2007.26.11.1565
DO - 10.7863/jum.2007.26.11.1565
M3 - Article
C2 - 17957051
AN - SCOPUS:38549153457
SN - 0278-4297
VL - 26
SP - 1565
EP - 1574
JO - Journal of Ultrasound in Medicine
JF - Journal of Ultrasound in Medicine
IS - 11
ER -