Development of additional primary tumors after 62 years in the first patient with retinoblastoma cured by radiation therapy

Daniel Albert, C. N.J. McGhee, J. M. Seddon, R. R. Weichselbaum

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10 Scopus citations


In the first well-documented case of bilateral retinoblastoma to be cured by X-irradiation of the nonenucleated eye, a basal cell carcinoma and then a squamous cell carcinoma of the eyelids developed 60 years after the original treatment. The patient, a 66-year-old man, had been treated by Verhoeff between 1917 and 1919. These new tumors may have been examples of second primary tumors, found in about 0.5% to 2.5% of patients with bilateral retinoblastoma, or they may have been coincidental. Because of the 60-year period between the patient's original treatment and the development of these tumors, it seems unlikely that they were the result of the irradiation.

Original languageEnglish (US)
Pages (from-to)189-196
Number of pages8
JournalAmerican journal of ophthalmology
Issue number2
Publication statusPublished - Jan 1 1984
Externally publishedYes


ASJC Scopus subject areas

  • Ophthalmology

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