Development of additional primary tumors after 62 years in the first patient with retinoblastoma cured by radiation therapy

Daniel Albert, C. N.J. McGhee, J. M. Seddon, R. R. Weichselbaum

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

In the first well-documented case of bilateral retinoblastoma to be cured by X-irradiation of the nonenucleated eye, a basal cell carcinoma and then a squamous cell carcinoma of the eyelids developed 60 years after the original treatment. The patient, a 66-year-old man, had been treated by Verhoeff between 1917 and 1919. These new tumors may have been examples of second primary tumors, found in about 0.5% to 2.5% of patients with bilateral retinoblastoma, or they may have been coincidental. Because of the 60-year period between the patient's original treatment and the development of these tumors, it seems unlikely that they were the result of the irradiation.

Original languageEnglish (US)
Pages (from-to)189-196
Number of pages8
JournalAmerican journal of ophthalmology
Volume97
Issue number2
DOIs
StatePublished - Jan 1 1984
Externally publishedYes

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Retinoblastoma
Radiotherapy
Neoplasms
Basal Cell Carcinoma
Eyelids
Squamous Cell Carcinoma
Therapeutics

ASJC Scopus subject areas

  • Ophthalmology

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Development of additional primary tumors after 62 years in the first patient with retinoblastoma cured by radiation therapy. / Albert, Daniel; McGhee, C. N.J.; Seddon, J. M.; Weichselbaum, R. R.

In: American journal of ophthalmology, Vol. 97, No. 2, 01.01.1984, p. 189-196.

Research output: Contribution to journalArticle

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