Development of additional pituitary hormone deficiencies in pediatric patients originally diagnosed with idiopathic isolated GH deficiency

Werner F. Blum, Cheri Deal, Alan G. Zimmermann, Elena P. Shavrikova, Christopher J. Child, Charmian A. Quigley, Stenvert L S Drop, Gordon B. Cutler, Ronald (Ron) Rosenfeld

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16 Scopus citations

Abstract

Objective: We assessed the characteristics of children initially diagnosed with idiopathic isolated GH deficiency (IGHD) who later developed additional (multiple) pituitary hormone deficiencies (MPHD). Design: Data were analyzed for 5805 pediatric patients with idiopathic IGHD, who were GH-naïve at baseline and GH-treated in the multinational, observational Genetics and Neuroendocrinology of Short Stature International Study. Methods: Development of MPHD was assessed from investigator diagnoses, adverse events, and concomitant medications. Analyses were performed for all patients and for those who developed MPHD within 4.5 years or had ≥3.5 years, follow-up and continued to have IGHD (4-year cohort). Results: MPHD developed in 118/5805 (2.0%) children overall, and in 96/1757 (5.5%) in the 4-year cohort. Patients who developed MPHD had more profound GHD, with decreased height SDS, IGF1 SDS and peak stimulated GH, and greater height decrement vs target, compared with children who continued to have IGHD (P

Original languageEnglish (US)
Pages (from-to)13-21
Number of pages9
JournalEuropean Journal of Endocrinology
Volume170
Issue number1
DOIs
Publication statusPublished - Jan 2014

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ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Blum, W. F., Deal, C., Zimmermann, A. G., Shavrikova, E. P., Child, C. J., Quigley, C. A., ... Rosenfeld, R. R. (2014). Development of additional pituitary hormone deficiencies in pediatric patients originally diagnosed with idiopathic isolated GH deficiency. European Journal of Endocrinology, 170(1), 13-21. https://doi.org/10.1530/EJE-13-0643