Development of a small implantable right ventricular assist device

Kiyotaka Fukamachi, David J. Horvath, Alex L. Massiello, Yoshio Ootaki, Keiji Kamohara, Masatoshi Akiyama, Firas Zahr, Michael W. Kopcak, Raymond Dessoffy, Ji Feng Chen, Stephen Benefit, Leonard A.R. Golding

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

The purpose of this program is to design, develop, and clinically evaluate a new, implantable right ventricular assist device (RVAD) that can be used as a component of an implantable biventricular assist device for patients with severe biventricular heart failure. The initial phase of this program resulted in a prototype RVAD, named DexAide, a modified version of the CorAide left ventricular assist device. In vitro testing was performed in a stand-alone circuit and in a true RVAD mode to evaluate pump performance. Pump flow and power were measured under various afterload and pump speed conditions. The pump performance requirements of 2 to 6 l/min and a pressure rise of 20 to 60 mm Hg were successfully met with pump speeds between 1,800 and 3,200 rpm. The nominal design point of 4 l/min and 40 mm Hg pressure rise was achieved at 2,450 ± 70 rpm with a power consumption of 3.0 ± 0.2 W. The initial in vitro testing met the design criteria for the new DexAide RVAD. Initial in vivo testing is under way, which will be followed by preclinical readiness testing and a pilot clinical trial in this 5-year program.

Original languageEnglish (US)
Pages (from-to)730-735
Number of pages6
JournalASAIO Journal
Volume51
Issue number6
DOIs
StatePublished - Nov 2005

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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    Fukamachi, K., Horvath, D. J., Massiello, A. L., Ootaki, Y., Kamohara, K., Akiyama, M., Zahr, F., Kopcak, M. W., Dessoffy, R., Chen, J. F., Benefit, S., & Golding, L. A. R. (2005). Development of a small implantable right ventricular assist device. ASAIO Journal, 51(6), 730-735. https://doi.org/10.1097/01.mat.0000181031.66900.b6