Development and aging of the eye in mice with inherited optic nerve aplasia: Histopathological studies

Jerry Silver, Stirling M. Puck, Daniel M. Albert

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

We have examined the morphological development of optic nerve aplasia in a subpopulation (10-20%) of anophthalmic mice (Strain ZRDCT-AN) that develop microphthalmia. During embryonic stages the optic fissure in microphthalmic mutants did not involute into the optic stalk. Even in the absence of a proper fissure, early differentiation of the various retinal elements was not disturbed. Subsequently, however, the optic nerve fibers failed to exit from the eye in their appropriate position. Secondary changes in the retina, probably resulting from a failure of optic axons to reach their central targets, were near total loss of ganglion cells and variable attenuation of the other nuclear and plexiform layers. Retinal rosettes were also commonly present.

Original languageEnglish (US)
Pages (from-to)257-266
Number of pages10
JournalExperimental Eye Research
Volume38
Issue number3
DOIs
StatePublished - Mar 1984

Keywords

  • ganglion cell death
  • optic fissure malformation
  • optic nerve aplasia

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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