Determining thresholds for contrast agent collapse

Azzdine Y. Ammi; Jonathan Mamou; Grace I. Wang; Robin O. Cleveland; S. Lori Bridal; William D. O 'Brien

doi:10.1109/ULTSYM.2004.1417736

Determining thresholds for contrast agent collapse

Azzdine Y. Ammi, Jonathan Mamou, Grace I. Wang, Robin O. Cleveland, S. Lori Bridal, William D. O 'Brien

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Scopus citations

Abstract

Determining the threshold of fragmentation of ultrasound contrast agents is important for both imaging and therapeutic ultrasound applications. We detected acoustic emissions from Optison™ microbubbles that were insonified by pulses of ultrasound. Our observations suggest that when the microbubbles rupture, daughter bubbles are created which subsequently grow and then collapse on a time-scale of 1-5 μs. The emission from the "rebound" collapse occurs after the end of the excitation pulse and we used the presence of this signal to determine the thresholds for the shell rupture. These shell-disruption thresholds were found to increase with frequency and decrease with pulse length.

Original language	English (US)
Title of host publication	Proceedings - 2004 IEEE Ultrasonics Symposium
Subtitle of host publication	A Conference of the IEEE International Ultrasonics, Ferroelectrics, and Frequency Control Society, UFFC-S
Editors	M.P. Yuhas
Pages	346-349
Number of pages	4
DOIs	https://doi.org/10.1109/ULTSYM.2004.1417736
State	Published - 2004
Externally published	Yes
Event	2004 IEEE Ultrasonics Symposium - Montreal, Que., Canada Duration: Aug 23 2004 → Aug 27 2004

Publication series

Name	Proceedings - IEEE Ultrasonics Symposium
Volume	1
ISSN (Print)	1051-0117

Other

Other	2004 IEEE Ultrasonics Symposium
Country/Territory	Canada
City	Montreal, Que.
Period	8/23/04 → 8/27/04

ASJC Scopus subject areas

Acoustics and Ultrasonics

Access to Document

10.1109/ULTSYM.2004.1417736

Cite this

Ammi, A. Y., Mamou, J., Wang, G. I., Cleveland, R. O., Bridal, S. L., & O 'Brien, W. D. (2004). Determining thresholds for contrast agent collapse. In M. P. Yuhas (Ed.), Proceedings - 2004 IEEE Ultrasonics Symposium: A Conference of the IEEE International Ultrasonics, Ferroelectrics, and Frequency Control Society, UFFC-S (pp. 346-349). Article U1-D-3 (Proceedings - IEEE Ultrasonics Symposium; Vol. 1). https://doi.org/10.1109/ULTSYM.2004.1417736

Determining thresholds for contrast agent collapse. / Ammi, Azzdine Y.; Mamou, Jonathan; Wang, Grace I. et al.
Proceedings - 2004 IEEE Ultrasonics Symposium: A Conference of the IEEE International Ultrasonics, Ferroelectrics, and Frequency Control Society, UFFC-S. ed. / M.P. Yuhas. 2004. p. 346-349 U1-D-3 (Proceedings - IEEE Ultrasonics Symposium; Vol. 1).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Ammi, AY, Mamou, J, Wang, GI, Cleveland, RO, Bridal, SL & O 'Brien, WD 2004, Determining thresholds for contrast agent collapse. in MP Yuhas (ed.), Proceedings - 2004 IEEE Ultrasonics Symposium: A Conference of the IEEE International Ultrasonics, Ferroelectrics, and Frequency Control Society, UFFC-S., U1-D-3, Proceedings - IEEE Ultrasonics Symposium, vol. 1, pp. 346-349, 2004 IEEE Ultrasonics Symposium, Montreal, Que., Canada, 8/23/04. https://doi.org/10.1109/ULTSYM.2004.1417736

Ammi AY, Mamou J, Wang GI, Cleveland RO, Bridal SL, O 'Brien WD. Determining thresholds for contrast agent collapse. In Yuhas MP, editor, Proceedings - 2004 IEEE Ultrasonics Symposium: A Conference of the IEEE International Ultrasonics, Ferroelectrics, and Frequency Control Society, UFFC-S. 2004. p. 346-349. U1-D-3. (Proceedings - IEEE Ultrasonics Symposium). doi: 10.1109/ULTSYM.2004.1417736

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AB - Determining the threshold of fragmentation of ultrasound contrast agents is important for both imaging and therapeutic ultrasound applications. We detected acoustic emissions from Optison™ microbubbles that were insonified by pulses of ultrasound. Our observations suggest that when the microbubbles rupture, daughter bubbles are created which subsequently grow and then collapse on a time-scale of 1-5 μs. The emission from the "rebound" collapse occurs after the end of the excitation pulse and we used the presence of this signal to determine the thresholds for the shell rupture. These shell-disruption thresholds were found to increase with frequency and decrease with pulse length.

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Determining thresholds for contrast agent collapse

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