Determining thresholds for contrast agent collapse

Azzdine Ammi, Jonathan Mamou, Grace I. Wang, Robin O. Cleveland, S. Lori Bridal, William D. O 'Brien

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Determining the threshold of fragmentation of ultrasound contrast agents is important for both imaging and therapeutic ultrasound applications. We detected acoustic emissions from Optison™ microbubbles that were insonified by pulses of ultrasound. Our observations suggest that when the microbubbles rupture, daughter bubbles are created which subsequently grow and then collapse on a time-scale of 1-5 μs. The emission from the "rebound" collapse occurs after the end of the excitation pulse and we used the presence of this signal to determine the thresholds for the shell rupture. These shell-disruption thresholds were found to increase with frequency and decrease with pulse length.

Original languageEnglish (US)
Title of host publicationProceedings - IEEE Ultrasonics Symposium
EditorsM.P. Yuhas
Pages346-349
Number of pages4
Volume1
DOIs
StatePublished - 2004
Externally publishedYes
Event2004 IEEE Ultrasonics Symposium - Montreal, Que., Canada
Duration: Aug 23 2004Aug 27 2004

Other

Other2004 IEEE Ultrasonics Symposium
CountryCanada
CityMontreal, Que.
Period8/23/048/27/04

Fingerprint

Ultrasonics
Acoustic emissions
Imaging techniques

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Ammi, A., Mamou, J., Wang, G. I., Cleveland, R. O., Bridal, S. L., & O 'Brien, W. D. (2004). Determining thresholds for contrast agent collapse. In M. P. Yuhas (Ed.), Proceedings - IEEE Ultrasonics Symposium (Vol. 1, pp. 346-349). [U1-D-3] https://doi.org/10.1109/ULTSYM.2004.1417736

Determining thresholds for contrast agent collapse. / Ammi, Azzdine; Mamou, Jonathan; Wang, Grace I.; Cleveland, Robin O.; Bridal, S. Lori; O 'Brien, William D.

Proceedings - IEEE Ultrasonics Symposium. ed. / M.P. Yuhas. Vol. 1 2004. p. 346-349 U1-D-3.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Ammi, A, Mamou, J, Wang, GI, Cleveland, RO, Bridal, SL & O 'Brien, WD 2004, Determining thresholds for contrast agent collapse. in MP Yuhas (ed.), Proceedings - IEEE Ultrasonics Symposium. vol. 1, U1-D-3, pp. 346-349, 2004 IEEE Ultrasonics Symposium, Montreal, Que., Canada, 8/23/04. https://doi.org/10.1109/ULTSYM.2004.1417736
Ammi A, Mamou J, Wang GI, Cleveland RO, Bridal SL, O 'Brien WD. Determining thresholds for contrast agent collapse. In Yuhas MP, editor, Proceedings - IEEE Ultrasonics Symposium. Vol. 1. 2004. p. 346-349. U1-D-3 https://doi.org/10.1109/ULTSYM.2004.1417736
Ammi, Azzdine ; Mamou, Jonathan ; Wang, Grace I. ; Cleveland, Robin O. ; Bridal, S. Lori ; O 'Brien, William D. / Determining thresholds for contrast agent collapse. Proceedings - IEEE Ultrasonics Symposium. editor / M.P. Yuhas. Vol. 1 2004. pp. 346-349
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