Determination of tissue optical properties by piezoelectric detection of laser-induced stress waves

Alexander A. Oraevsky, Steven L. Jacques, Frank K. Tittel

Research output: Chapter in Book/Report/Conference proceedingConference contribution

107 Scopus citations

Abstract

A technique is described for the measurement of optical properties in clear and turbid media based on time-resolved detection of acoustic transients. Thermal expansion of the irradiated volume of a sample heated by short laser pulses causes a pressure-rise that is proportionally to the laser fluence and the absorption coefficient in the sample. The exponential profile of the acoustic signal formed by the initial stress distribution corresponds to z-axial light distribution in the irradiated volume. Therefore, the absorption and scattering properties of tissue can be determined from the profile and amplitude of the acoustic signals induced by the laser pulses. Stress waves generated in phantom aqueous medium and biological tissues by laser pulses were detected by a broad-band lithium niobate acoustic transducer. The results indicate that absorption coefficients in soft biological tissues in the near infrared spectral range are significantly (5 - 10 times) lower as compared to previously reported from integrating sphere measurements.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
PublisherPubl by Society of Photo-Optical Instrumentation Engineers
Pages86-101
Number of pages16
ISBN (Print)0819411094, 9780819411099
DOIs
StatePublished - 1993
Externally publishedYes
EventLaser-Tissue Interaction IV - Los Angeles, CA, USA
Duration: Jan 18 1993Jan 20 1993

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume1882
ISSN (Print)0277-786X

Other

OtherLaser-Tissue Interaction IV
CityLos Angeles, CA, USA
Period1/18/931/20/93

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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