Determination of the MRI contrast agent concentration time course in vivo following bolus injection: Effect of equilibrium transcytolemmal water exchange

Charles S. Landis, Xin Li, Frank W. Telang, Jeffrey A. Coderre, Peggy L. Micca, William D. Rooney, Lawrence L. Latour, Gábor Vétek, Ildikó Pályka, Charles S. Springer

Research output: Contribution to journalArticlepeer-review

173 Scopus citations

Abstract

For bolus-tracking studies, it is commonly assumed that CR concentration bears a linear relationship with the measured (usually longitudinal) 1H2O relaxation rate constant, R1/(*) ≡(T1/(*))-1. This requires that equilibrium transcytolemmal water exchange be in the fast exchange limit (FXL). However, though systems remain in fast exchange, the FXL will not usually obtain. Here, the consequences are considered: 1) the measurement of R1/(*) itself can be affected, 2) the resultant non-linear [CR]-dependence causes significant error by assuming FXL, 3) the thermodynamic [CR] (based on the space in which CR is actually distributed) can be determined, 4) transcytolemmal water permeability may be estimated, and 5) the pharmacokinetic parameters can be factored. For a 30-sec, 0.17 mmol/kg dose of GdDTPA2-, the FXL assumption underestimates the [CR] maximum in rat thigh muscle by a factor of almost two. Similar results are obtained for a rat brain GS-9L gliosarcoma tumor model.

Original languageEnglish (US)
Pages (from-to)563-574
Number of pages12
JournalMagnetic Resonance in Medicine
Volume44
Issue number4
DOIs
StatePublished - Jan 1 2000

Keywords

  • Bolus-tracking
  • Concentration
  • Contrast reagent
  • Transcytolemmal water exchange

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Determination of the MRI contrast agent concentration time course in vivo following bolus injection: Effect of equilibrium transcytolemmal water exchange'. Together they form a unique fingerprint.

Cite this