Determination of the blood oxygenation in the brain by time-resolved reflectance spectroscopy: contribution of vascular absorption and tissue background absorption

Hanli Liu, Andreas H. Hielscher, Bertrand Beauvoit, Li Hong Wang, Steven L. Jacques, Frank K. Tittel, Britton Chance

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The possibility of measuring the blood oxygenation in the brain with near infrared light has been studied. The goal of this study was to quantify the influence of different brain layers on brain blood oxygenation measurements. Experimental results obtained from time resolved reflectance measurements on layered tissue phantoms were compared to Monte Carlo simulations of layered models, diffusion theory, and in vivo measurements on the human head. Both the experimental results and simulations show that the absorption coefficient μ a, which is closely related to the blood oxygenation, of deeper layers can be accessed in the time domain. Thus fitting analytical expressions found from diffusion theory only to the late part of the time resolved reflectance allows us to determine μa and subsequently the blood oxygenation of the deepest medium (e.g. brain tissue).

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
PublisherSociety of Photo-Optical Instrumentation Engineers
Pages4-14
Number of pages11
ISBN (Print)081941431X
StatePublished - Dec 1 1994
Externally publishedYes
EventBiochemical Diagnostic Instrumentation - Los Angeles, CA, USA
Duration: Jan 24 1994Jan 24 1994

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume2136
ISSN (Print)0277-786X

Other

OtherBiochemical Diagnostic Instrumentation
CityLos Angeles, CA, USA
Period1/24/941/24/94

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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