Determination of cerebrospinal fluid production rate using a push‐pull perfusion procedure in the conscious rat

V. Baudrie, JB Roullet, Y. Goureau, F. Chaouloff, JL Elghozi

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Summary— The inulin dilution technique was used to determine the cerebrospinal fluid (CSF) production rate by means of a push‐pull cannula implanted into a lateral ventricle. Artificial CSF containing trace amount of 3H‐inulin was perfused for 2 h in conscious rats. 3H‐inulin in the effluent reached a plateau level depending on the CSF production rate. The control lateroventricular CSF production was 0.98 μl/min. Production was reduced to 0.34 μl/min during a perfusion with acetazolamide (l mM), a carbonic anhydrase inhibitor. 1990 Société Française de Pharmacologie et de Thérapeutique

Original languageEnglish (US)
Pages (from-to)269-274
Number of pages6
JournalFundamental & Clinical Pharmacology
Volume4
Issue number3
DOIs
StatePublished - 1990

Keywords

  • cerebrospinal fluid (CSF)
  • conscious rat
  • inulin
  • lateral ventricle
  • push‐pull perfusion

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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