Determination of asymmetric cavity volumes using real-time three-dimensional echocardiography: An in vitro balloon model study

Kesavan Prakash, Xiaokui Li, Aarti Hejmadi, Ikuo Hashimoto, David Sahn

Research output: Contribution to journalArticle

9 Scopus citations


Objectives: We designed a new in vitro model to test the accuracy and reproducibility of real-time three-dimensional (RT3D) ultrasound imaging for determining a variety of asymmetric cavity volumes with aneurysm. Methods: Fifteen individual balloon models mimicking ventricular aneurysm were filled with water (170-322.5 ml) without air bubbles and kept in a compressor pump. Compression of the models produced only a change in shape of the balloon and no change in volume. The models were scanned with RT3D echocardiography (RT3DE) and the images recorded on an optical disk. Volumes were measured off line in two phases; maximal compression, where there was maximal change in shape and nil compression, where there was minimal or no change in shape. Volumes were measured by manual tracing technique of the inner border of B-scan images and compared with the drained volume of water from the balloon. Results: There was a high correlation between the drained volume and measured volume at maximal compression (equivalent to end-systole, r = 0.99, y = 0.99x + 3.69, SEE = 6.5 ml), between the drained volume and measured volume at nil compression (equivalent to end-diastole, r = 0.99, y = 0.94x + 12.07, SEE = 5.9 ml), and between volumes measured at maximal and nil compressions (r = 0.99, y = 0.94x + 10.55, SEE = 4.6 ml). Conclusion: The results of this experiment show that RT3DE can accurately measure the volumes of a variety of asymmetric ventricular cavities.

Original languageEnglish (US)
Pages (from-to)257-263
Number of pages7
Issue number3
Publication statusPublished - Apr 2004



  • Real-time three-dimensional echocardiography
  • Ventricular aneurysm

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

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