Determinants of prolonged QT interval and their contribution to sudden death risk in coronary artery disease: The Oregon sudden unexpected death study

Sumeet S. Chugh, Kyndaron Reinier, Tejwant Singh, Audrey Uy-Evanado, Carmen Socoteanu, Dawn Peters, Ronald Mariani, Karen Gunson, Jonathan Jui

Research output: Contribution to journalArticle

158 Scopus citations

Abstract

Background - In a recent cohort study, prolongation of the corrected QT interval (QTc) was associated with an independent increased risk of sudden cardiac death (SCD). We evaluated determinants of prolonged QTc and the relationship of prolonged QTc to SCD risk among patients with coronary artery disease in the general population. Methods and Results - A case-control design was used. Cases were SCD patients with coronary artery disease among a metropolitan area of 1 000 000 residents (2002 to 2006); controls were area residents with coronary artery disease but no history of SCD. All cases were required to have an ECG suitable for QTc analysis before and unrelated to the occurrence of SCD. A total of 373 cases and 309 controls met criteria for analysis. Mean QTc was significantly longer in cases than in controls (450±45 versus 433±37 ms; P

Original languageEnglish (US)
Pages (from-to)663-670
Number of pages8
JournalCirculation
Volume119
Issue number5
DOIs
Publication statusPublished - Feb 10 2009

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Keywords

  • Coronary disease
  • Death, sudden
  • Diabetes mellitus
  • Drugs risk
  • Epidemiology
  • Population
  • Prescription

ASJC Scopus subject areas

  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

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