TY - JOUR
T1 - Determinants and clinical significance of flow via the fenestration in the Fontan pathway
T2 - A multimodality study
AU - Grosse-Wortmann, Lars
AU - Dragulescu, Andreea
AU - Drolet, Christian
AU - Chaturvedi, Rajiv
AU - Kotani, Yasuhiro
AU - Mertens, Luc
AU - Taylor, Katherine
AU - La Rotta, Gustavo
AU - Van Arsdell, Glen
AU - Redington, Andrew
AU - Yoo, Shi Joon
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2013/9/30
Y1 - 2013/9/30
N2 - Background: The use of a fenestration in the Fontan pathway remains controversial, partly because its hemodynamic effects and clinical consequences are insufficiently understood. The objective of this study was to quantify the magnitude of fenestration flow and to characterize its hemodynamic consequences after an intermediate interval after surgery. Methods: Twenty three patients with a fenestrated extracardiac conduit prospectively underwent investigation by cardiac magnetic resonance (CMR), echocardiography, and invasive manometry under the same general anesthetic 12±4 months after Fontan surgery. Fenestration flow was determined using phase contrast CMR by subtracting flow in the Fontan pathway above the fenestration from Fontan flow below the fenestration. Results: Fenestration flow constituted a mean of 31±12% (range 8-50%) of ventricular preload. It was associated with a lower Qp/Qs (r=-0.64, p=0.001) and oxygen saturation (r=-0.74, p<0.0001). Fenestration flow volume was correlated with pulmonary vascular resistance (r=0.45, p=0.04) and markers of ventricular diastolic function (early diastolic strain rate r=0.57, p=0.008 and ventricular untwist rate r=0.54, p=0.02). In 14 patients (61%) all of the net inferior vena cava flow and part of the superior vena cava flow were diverted into the systemic atrium and did not reach the lungs. Conclusions: Fenestration flow can be measured accurately with CMR. In two-thirds of the patients not only all of the inferior vena cava flow, but also some of the superior vena cava flow is diverted through the fenestration. Fenestration flow is driven by a balance between pulmonary vascular resistance and early diastolic ventricular function.
AB - Background: The use of a fenestration in the Fontan pathway remains controversial, partly because its hemodynamic effects and clinical consequences are insufficiently understood. The objective of this study was to quantify the magnitude of fenestration flow and to characterize its hemodynamic consequences after an intermediate interval after surgery. Methods: Twenty three patients with a fenestrated extracardiac conduit prospectively underwent investigation by cardiac magnetic resonance (CMR), echocardiography, and invasive manometry under the same general anesthetic 12±4 months after Fontan surgery. Fenestration flow was determined using phase contrast CMR by subtracting flow in the Fontan pathway above the fenestration from Fontan flow below the fenestration. Results: Fenestration flow constituted a mean of 31±12% (range 8-50%) of ventricular preload. It was associated with a lower Qp/Qs (r=-0.64, p=0.001) and oxygen saturation (r=-0.74, p<0.0001). Fenestration flow volume was correlated with pulmonary vascular resistance (r=0.45, p=0.04) and markers of ventricular diastolic function (early diastolic strain rate r=0.57, p=0.008 and ventricular untwist rate r=0.54, p=0.02). In 14 patients (61%) all of the net inferior vena cava flow and part of the superior vena cava flow were diverted into the systemic atrium and did not reach the lungs. Conclusions: Fenestration flow can be measured accurately with CMR. In two-thirds of the patients not only all of the inferior vena cava flow, but also some of the superior vena cava flow is diverted through the fenestration. Fenestration flow is driven by a balance between pulmonary vascular resistance and early diastolic ventricular function.
KW - Fenestration
KW - Fontan
KW - Magnetic resonance imaging
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U2 - 10.1016/j.ijcard.2012.10.008
DO - 10.1016/j.ijcard.2012.10.008
M3 - Article
C2 - 23164583
AN - SCOPUS:84885308075
SN - 0167-5273
VL - 168
SP - 811
EP - 817
JO - International Journal of Cardiology
JF - International Journal of Cardiology
IS - 2
ER -