Detection of nonexudative choroidal neovascularization in age-related macular degeneration with optical coherence tomography angiography

Research output: Contribution to journalArticle

99 Scopus citations

Abstract

Purpose: To evaluate eyes with age-related macular degeneration and high-risk characteristics for choroidal neovascularization (CNV) with optical coherence tomographic (OCT) angiography to determine whether earlier detection of CNV is possible. Methods: Eyes with drusen, pigmentary changes, and with CNV in the fellow eye were scanned with a 70-kHz spectral domain OCT system (Optovue RTVue-XR Avanti). The splitspectrum amplitude-decorrelation angiography (SSADA) algorithm was used to distinguish blood flow from static tissue. Two masked graders reviewed scans for CNV, defined as flow in the outer retinal/sub-RPE slab. Choroidal neovascularization flow area repeatability and between-grader reproducibility were calculated. Results: Of 32 eyes, 2 (6%) were found to have Type 1 CNV with OCT angiography. The lesions were not associated with leakage on fluorescein angiography or fluid on OCT. One case was followed for 8 months without treatment, and the CNV flow area enlarged slightly without fluid buildup on OCT or vision loss. Between-grader reproducibility of the CNV flow area was 9.4% (coefficient of variation) and within-visit repeatability was 5.2% (pooled coefficient of variation). Conclusion: Optical coherence tomographic angiography can detect the presence of nonexudative CNV, lesions difficult to identify with fluorescein angiography and OCT. Further study is needed to understand the significance and natural history of these lesions.

Original languageEnglish (US)
Pages (from-to)2204-2211
Number of pages8
JournalRetina
Volume35
Issue number11
DOIs
StatePublished - Oct 27 2015

Keywords

  • Age-related macular degeneration
  • Choroidal neovascularization
  • Diagnostic retinal
  • Imaging
  • Optical coherence tomography angiography

ASJC Scopus subject areas

  • Ophthalmology

Fingerprint Dive into the research topics of 'Detection of nonexudative choroidal neovascularization in age-related macular degeneration with optical coherence tomography angiography'. Together they form a unique fingerprint.

  • Cite this