Detection of experimental atherosclerosis with indium-111 radiolabelled hematoporphyrin derivative

R. T. Palac, L. L. Gray, F. E. Turner, Paul Brown, M. R. Malinow, H. Demots

Research output: Contribution to journalArticle

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Abstract

It has been observed that atherosclerotic lesions (AL) concentrate certain porphyrins. We evaluated the usefulness of111In-labelled Photofrin II (PFII), a porphyrin derived from haematoporphyrin derivative, for detection of experimental AL in cholesterol fed rabbits. Three groups of rabbits were studied: non-atherosclerotic (h=3), 6 and 12 week cholesterol fed (n=4, 3).111In-PFII was injected intravenously and gamma camera images were obtained at 24 and 48 h. At 48 h, explanted aortas were also imaged. Aortic arch (AA) to background (BKG) count ratios were calculated from images of the whole body and explanted aortas. AA/BKG ratios were significantly higher in the 12 week cholesterol fed rabbits (3.9±0.72 @ 24 h) and (4.0±0.67 @ 48 h) than in the non-atherosclerotic rabbits (2.2±0.07 @ 24 h) and (2.3±0.18 @ 48 h) (p 111In-PFII concentrates in AL as early as 24 h after injection and has the potential to be used as an imaging agent for experimental atherosclerosis.

Original languageEnglish (US)
Pages (from-to)841-850
Number of pages10
JournalNuclear Medicine Communications
Volume10
Issue number11
StatePublished - 1989

Fingerprint

Hematoporphyrin Derivative
Indium
Dihematoporphyrin Ether
Atherosclerosis
Rabbits
Cholesterol
Porphyrins
Thoracic Aorta
Aorta
Gamma Cameras
Body Image
Injections

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Palac, R. T., Gray, L. L., Turner, F. E., Brown, P., Malinow, M. R., & Demots, H. (1989). Detection of experimental atherosclerosis with indium-111 radiolabelled hematoporphyrin derivative. Nuclear Medicine Communications, 10(11), 841-850.

Detection of experimental atherosclerosis with indium-111 radiolabelled hematoporphyrin derivative. / Palac, R. T.; Gray, L. L.; Turner, F. E.; Brown, Paul; Malinow, M. R.; Demots, H.

In: Nuclear Medicine Communications, Vol. 10, No. 11, 1989, p. 841-850.

Research output: Contribution to journalArticle

Palac, RT, Gray, LL, Turner, FE, Brown, P, Malinow, MR & Demots, H 1989, 'Detection of experimental atherosclerosis with indium-111 radiolabelled hematoporphyrin derivative', Nuclear Medicine Communications, vol. 10, no. 11, pp. 841-850.
Palac, R. T. ; Gray, L. L. ; Turner, F. E. ; Brown, Paul ; Malinow, M. R. ; Demots, H. / Detection of experimental atherosclerosis with indium-111 radiolabelled hematoporphyrin derivative. In: Nuclear Medicine Communications. 1989 ; Vol. 10, No. 11. pp. 841-850.
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