Detection of Calcified and Noncalcified Coronary Atherosclerotic Plaque by Contrast-Enhanced, Submillimeter Multidetector Spiral Computed Tomography: A Segment-Based Comparison with Intravascular Ultrasound

Stephan Achenbach, Fabian Moselewski, Dieter Ropers, Maros Ferencik, Udo Hoffmann, Briain MacNeill, Karsten Pohle, Ulrich Baum, Katharina Anders, Ik Kyung Jang, Werner G. Daniel, Thomas J. Brady

Research output: Contribution to journalArticle

679 Citations (Scopus)

Abstract

Background-We investigated the ability of multidetector spiral computed tomography (MDCT) to detect atherosclerotic plaque in nonstenotic coronary arteries. Methods and Results-In 22 patients without significant coronary stenoses, contrast-enhanced MDCT (0.75-mm collimation, 420-ms rotation) and intravascular ultrasound (IVUS) of one coronary artery were performed. A total of 83 coronary segments were imaged by IVUS (left main, 19; left anterior descending, 51; left circumflex, 4; right coronary, 9). MDCT data sets were evaluated for the presence and volume of plaque in the coronary artery segments. Results were compared with IVUS in a blinded fashion. For the detection of segments with any plaque, MDCT had a sensitivity of 82% (41 of 50) and specificity of 88% (29 of 33). For calcified plaque, sensitivity was 94% (33 of 36) and specificity 94% (45 of 47). Coronary segments containing noncalcified plaque were detected with a sensitivity of 78% (35 of 45) and specificity of 87% (33 of 38), but presence of exclusively noncalcified plaque was detected with only 53% sensitivity (8 of 15). If analysis was limited to the 41 proximal segments (segments 1, 5, 6, and 11 according to American Heart Association classification), sensitivity and specificity were 92% and 88% for any plaque, 95% and 91% for calcified plaque, and 91% and 89% for noncalcified plaque. MDCT substantially underestimated plaque volume per segment as compared with IVUS (24±35 mm3 versus 43±60 mm3, P

Original languageEnglish (US)
Pages (from-to)14-17
Number of pages4
JournalCirculation
Volume109
Issue number1
DOIs
StatePublished - Jan 6 2004
Externally publishedYes

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Multidetector Computed Tomography
Spiral Computed Tomography
Atherosclerotic Plaques
Coronary Vessels
Coronary Stenosis
Sensitivity and Specificity

Keywords

  • Atherosclerosis
  • Coronary disease
  • Tomography

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Detection of Calcified and Noncalcified Coronary Atherosclerotic Plaque by Contrast-Enhanced, Submillimeter Multidetector Spiral Computed Tomography : A Segment-Based Comparison with Intravascular Ultrasound. / Achenbach, Stephan; Moselewski, Fabian; Ropers, Dieter; Ferencik, Maros; Hoffmann, Udo; MacNeill, Briain; Pohle, Karsten; Baum, Ulrich; Anders, Katharina; Jang, Ik Kyung; Daniel, Werner G.; Brady, Thomas J.

In: Circulation, Vol. 109, No. 1, 06.01.2004, p. 14-17.

Research output: Contribution to journalArticle

Achenbach, Stephan ; Moselewski, Fabian ; Ropers, Dieter ; Ferencik, Maros ; Hoffmann, Udo ; MacNeill, Briain ; Pohle, Karsten ; Baum, Ulrich ; Anders, Katharina ; Jang, Ik Kyung ; Daniel, Werner G. ; Brady, Thomas J. / Detection of Calcified and Noncalcified Coronary Atherosclerotic Plaque by Contrast-Enhanced, Submillimeter Multidetector Spiral Computed Tomography : A Segment-Based Comparison with Intravascular Ultrasound. In: Circulation. 2004 ; Vol. 109, No. 1. pp. 14-17.
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abstract = "Background-We investigated the ability of multidetector spiral computed tomography (MDCT) to detect atherosclerotic plaque in nonstenotic coronary arteries. Methods and Results-In 22 patients without significant coronary stenoses, contrast-enhanced MDCT (0.75-mm collimation, 420-ms rotation) and intravascular ultrasound (IVUS) of one coronary artery were performed. A total of 83 coronary segments were imaged by IVUS (left main, 19; left anterior descending, 51; left circumflex, 4; right coronary, 9). MDCT data sets were evaluated for the presence and volume of plaque in the coronary artery segments. Results were compared with IVUS in a blinded fashion. For the detection of segments with any plaque, MDCT had a sensitivity of 82{\%} (41 of 50) and specificity of 88{\%} (29 of 33). For calcified plaque, sensitivity was 94{\%} (33 of 36) and specificity 94{\%} (45 of 47). Coronary segments containing noncalcified plaque were detected with a sensitivity of 78{\%} (35 of 45) and specificity of 87{\%} (33 of 38), but presence of exclusively noncalcified plaque was detected with only 53{\%} sensitivity (8 of 15). If analysis was limited to the 41 proximal segments (segments 1, 5, 6, and 11 according to American Heart Association classification), sensitivity and specificity were 92{\%} and 88{\%} for any plaque, 95{\%} and 91{\%} for calcified plaque, and 91{\%} and 89{\%} for noncalcified plaque. MDCT substantially underestimated plaque volume per segment as compared with IVUS (24±35 mm3 versus 43±60 mm3, P",
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T1 - Detection of Calcified and Noncalcified Coronary Atherosclerotic Plaque by Contrast-Enhanced, Submillimeter Multidetector Spiral Computed Tomography

T2 - A Segment-Based Comparison with Intravascular Ultrasound

AU - Achenbach, Stephan

AU - Moselewski, Fabian

AU - Ropers, Dieter

AU - Ferencik, Maros

AU - Hoffmann, Udo

AU - MacNeill, Briain

AU - Pohle, Karsten

AU - Baum, Ulrich

AU - Anders, Katharina

AU - Jang, Ik Kyung

AU - Daniel, Werner G.

AU - Brady, Thomas J.

PY - 2004/1/6

Y1 - 2004/1/6

N2 - Background-We investigated the ability of multidetector spiral computed tomography (MDCT) to detect atherosclerotic plaque in nonstenotic coronary arteries. Methods and Results-In 22 patients without significant coronary stenoses, contrast-enhanced MDCT (0.75-mm collimation, 420-ms rotation) and intravascular ultrasound (IVUS) of one coronary artery were performed. A total of 83 coronary segments were imaged by IVUS (left main, 19; left anterior descending, 51; left circumflex, 4; right coronary, 9). MDCT data sets were evaluated for the presence and volume of plaque in the coronary artery segments. Results were compared with IVUS in a blinded fashion. For the detection of segments with any plaque, MDCT had a sensitivity of 82% (41 of 50) and specificity of 88% (29 of 33). For calcified plaque, sensitivity was 94% (33 of 36) and specificity 94% (45 of 47). Coronary segments containing noncalcified plaque were detected with a sensitivity of 78% (35 of 45) and specificity of 87% (33 of 38), but presence of exclusively noncalcified plaque was detected with only 53% sensitivity (8 of 15). If analysis was limited to the 41 proximal segments (segments 1, 5, 6, and 11 according to American Heart Association classification), sensitivity and specificity were 92% and 88% for any plaque, 95% and 91% for calcified plaque, and 91% and 89% for noncalcified plaque. MDCT substantially underestimated plaque volume per segment as compared with IVUS (24±35 mm3 versus 43±60 mm3, P

AB - Background-We investigated the ability of multidetector spiral computed tomography (MDCT) to detect atherosclerotic plaque in nonstenotic coronary arteries. Methods and Results-In 22 patients without significant coronary stenoses, contrast-enhanced MDCT (0.75-mm collimation, 420-ms rotation) and intravascular ultrasound (IVUS) of one coronary artery were performed. A total of 83 coronary segments were imaged by IVUS (left main, 19; left anterior descending, 51; left circumflex, 4; right coronary, 9). MDCT data sets were evaluated for the presence and volume of plaque in the coronary artery segments. Results were compared with IVUS in a blinded fashion. For the detection of segments with any plaque, MDCT had a sensitivity of 82% (41 of 50) and specificity of 88% (29 of 33). For calcified plaque, sensitivity was 94% (33 of 36) and specificity 94% (45 of 47). Coronary segments containing noncalcified plaque were detected with a sensitivity of 78% (35 of 45) and specificity of 87% (33 of 38), but presence of exclusively noncalcified plaque was detected with only 53% sensitivity (8 of 15). If analysis was limited to the 41 proximal segments (segments 1, 5, 6, and 11 according to American Heart Association classification), sensitivity and specificity were 92% and 88% for any plaque, 95% and 91% for calcified plaque, and 91% and 89% for noncalcified plaque. MDCT substantially underestimated plaque volume per segment as compared with IVUS (24±35 mm3 versus 43±60 mm3, P

KW - Atherosclerosis

KW - Coronary disease

KW - Tomography

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