Detection of aminoglycoside ototoxicity by high-frequency auditory evaluation: Selected case studies

Stephen A. Fausti, Bruce Z. Rappaport, Martin A. Schechter, Richard H. Frey, Thomas T. Ward, Robert E. Brummett

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

A practical monitoring procedure utilizing frequencies higher than those tested by conventional audiometry for the detection of ototoxicity has the potential for preventing or minimizing irreversible communication deficits in patients receiving aminoglycoside antibiotic therapy. If ototoxicity produced by these drugs could be detected before it progresses to involve the frequencies essential for communication, it might be possible to lower the dose or to change to another antibiotic to prevent a permanently handicapping hearing impairment. From a total of 77 patients monitored by serial audiograms, three case studies illustrate the various types of auditory sensitivity changes observed with high-frequency audiometry. Ototoxicity was generally detected by high-frequency auditory testing before it could be detected by conventional audiometric procedures. These cases demonstrate the utility of monitoring audition at frequencies higher than those tested conventionally in patients receiving aminoglycoside antibiotics.

Original languageEnglish (US)
Pages (from-to)177-182
Number of pages6
JournalAmerican Journal of Otolaryngology--Head and Neck Medicine and Surgery
Volume5
Issue number3
DOIs
StatePublished - Jan 1 1984

ASJC Scopus subject areas

  • Otorhinolaryngology

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