Detection and characterization of additional DNA polymorphisms in the dopamine D2 receptor gene

Xue Ya Hauge, David Grandy, James H. Eubanks, Glen A. Evans, Olivier Civelli, Michael Litt

    Research output: Contribution to journalArticle

    158 Citations (Scopus)

    Abstract

    The gene encoding the dopamine D2 receptor (DRD2) has been suggested as a candidate gene for several mental disorders. We previously described the cloning and chromosomal mapping (to 11q22-q23) of a human DRD2 gene as well as its use for the detection of a two-allele TaqI RFLP with a minor allele frequency of 0.24, corresponding to a PIC of 0.30. Family linkage studies utilizing DRD2 would be facilitated if the PIC of the DRD2 locus were increased. To this end, we have used additional phage and cosmid clones in the vicinity of DRD2 to identify a new two-allele TaqI RFLP as well as a TG microsatellite polymorphism with a PIC of 0.62. We report localizations of the three polymorphisms on the restriction map of the DRD2 locus. The TaqI RFLPs are in apparent linkage equilibrium with the microsatellite, yielding a highly informative compound marker locus with a PIC of 0.76.

    Original languageEnglish (US)
    Pages (from-to)527-530
    Number of pages4
    JournalGenomics
    Volume10
    Issue number3
    DOIs
    StatePublished - 1991

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    Dopamine D2 Receptors
    Restriction Fragment Length Polymorphisms
    Microsatellite Repeats
    DNA
    Alleles
    Genes
    Cosmids
    Gene Frequency
    Mental Disorders
    Bacteriophages
    Organism Cloning
    Clone Cells

    ASJC Scopus subject areas

    • Genetics

    Cite this

    Hauge, X. Y., Grandy, D., Eubanks, J. H., Evans, G. A., Civelli, O., & Litt, M. (1991). Detection and characterization of additional DNA polymorphisms in the dopamine D2 receptor gene. Genomics, 10(3), 527-530. https://doi.org/10.1016/0888-7543(91)90431-D

    Detection and characterization of additional DNA polymorphisms in the dopamine D2 receptor gene. / Hauge, Xue Ya; Grandy, David; Eubanks, James H.; Evans, Glen A.; Civelli, Olivier; Litt, Michael.

    In: Genomics, Vol. 10, No. 3, 1991, p. 527-530.

    Research output: Contribution to journalArticle

    Hauge, XY, Grandy, D, Eubanks, JH, Evans, GA, Civelli, O & Litt, M 1991, 'Detection and characterization of additional DNA polymorphisms in the dopamine D2 receptor gene', Genomics, vol. 10, no. 3, pp. 527-530. https://doi.org/10.1016/0888-7543(91)90431-D
    Hauge, Xue Ya ; Grandy, David ; Eubanks, James H. ; Evans, Glen A. ; Civelli, Olivier ; Litt, Michael. / Detection and characterization of additional DNA polymorphisms in the dopamine D2 receptor gene. In: Genomics. 1991 ; Vol. 10, No. 3. pp. 527-530.
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