Detection and characterization of additional DNA polymorphisms in the dopamine D2 receptor gene

Xue Ya Hauge; David K. Grandy; James H. Eubanks; Glen A. Evans; Olivier Civelli; Michael Litt

doi:10.1016/0888-7543(91)90431-D

Detection and characterization of additional DNA polymorphisms in the dopamine D2 receptor gene

Xue Ya Hauge, David K. Grandy, James H. Eubanks, Glen A. Evans, Olivier Civelli, Michael Litt

Research output: Contribution to journal › Article › peer-review

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Abstract

The gene encoding the dopamine D2 receptor (DRD2) has been suggested as a candidate gene for several mental disorders. We previously described the cloning and chromosomal mapping (to 11q22-q23) of a human DRD2 gene as well as its use for the detection of a two-allele TaqI RFLP with a minor allele frequency of 0.24, corresponding to a PIC of 0.30. Family linkage studies utilizing DRD2 would be facilitated if the PIC of the DRD2 locus were increased. To this end, we have used additional phage and cosmid clones in the vicinity of DRD2 to identify a new two-allele TaqI RFLP as well as a TG microsatellite polymorphism with a PIC of 0.62. We report localizations of the three polymorphisms on the restriction map of the DRD2 locus. The TaqI RFLPs are in apparent linkage equilibrium with the microsatellite, yielding a highly informative compound marker locus with a PIC of 0.76.

Original language	English (US)
Pages (from-to)	527-530
Number of pages	4
Journal	Genomics
Volume	10
Issue number	3
DOIs	https://doi.org/10.1016/0888-7543(91)90431-D
State	Published - Jul 1991
Externally published	Yes

ASJC Scopus subject areas

Genetics

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title = "Detection and characterization of additional DNA polymorphisms in the dopamine D2 receptor gene",

abstract = "The gene encoding the dopamine D2 receptor (DRD2) has been suggested as a candidate gene for several mental disorders. We previously described the cloning and chromosomal mapping (to 11q22-q23) of a human DRD2 gene as well as its use for the detection of a two-allele TaqI RFLP with a minor allele frequency of 0.24, corresponding to a PIC of 0.30. Family linkage studies utilizing DRD2 would be facilitated if the PIC of the DRD2 locus were increased. To this end, we have used additional phage and cosmid clones in the vicinity of DRD2 to identify a new two-allele TaqI RFLP as well as a TG microsatellite polymorphism with a PIC of 0.62. We report localizations of the three polymorphisms on the restriction map of the DRD2 locus. The TaqI RFLPs are in apparent linkage equilibrium with the microsatellite, yielding a highly informative compound marker locus with a PIC of 0.76.",

author = "Hauge, {Xue Ya} and Grandy, {David K.} and Eubanks, {James H.} and Evans, {Glen A.} and Olivier Civelli and Michael Litt",

note = "Funding Information: This work was supported by NIH NS25370-02 (to M.L.) and NIMH Grant thank Lynn Jorde for helpful discussions.",

year = "1991",

month = jul,

doi = "10.1016/0888-7543(91)90431-D",

language = "English (US)",

volume = "10",

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journal = "Genomics",

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publisher = "Academic Press Inc.",

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T1 - Detection and characterization of additional DNA polymorphisms in the dopamine D2 receptor gene

AU - Hauge, Xue Ya

AU - Grandy, David K.

AU - Eubanks, James H.

AU - Evans, Glen A.

AU - Civelli, Olivier

AU - Litt, Michael

N1 - Funding Information: This work was supported by NIH NS25370-02 (to M.L.) and NIMH Grant thank Lynn Jorde for helpful discussions.

PY - 1991/7

Y1 - 1991/7

N2 - The gene encoding the dopamine D2 receptor (DRD2) has been suggested as a candidate gene for several mental disorders. We previously described the cloning and chromosomal mapping (to 11q22-q23) of a human DRD2 gene as well as its use for the detection of a two-allele TaqI RFLP with a minor allele frequency of 0.24, corresponding to a PIC of 0.30. Family linkage studies utilizing DRD2 would be facilitated if the PIC of the DRD2 locus were increased. To this end, we have used additional phage and cosmid clones in the vicinity of DRD2 to identify a new two-allele TaqI RFLP as well as a TG microsatellite polymorphism with a PIC of 0.62. We report localizations of the three polymorphisms on the restriction map of the DRD2 locus. The TaqI RFLPs are in apparent linkage equilibrium with the microsatellite, yielding a highly informative compound marker locus with a PIC of 0.76.

AB - The gene encoding the dopamine D2 receptor (DRD2) has been suggested as a candidate gene for several mental disorders. We previously described the cloning and chromosomal mapping (to 11q22-q23) of a human DRD2 gene as well as its use for the detection of a two-allele TaqI RFLP with a minor allele frequency of 0.24, corresponding to a PIC of 0.30. Family linkage studies utilizing DRD2 would be facilitated if the PIC of the DRD2 locus were increased. To this end, we have used additional phage and cosmid clones in the vicinity of DRD2 to identify a new two-allele TaqI RFLP as well as a TG microsatellite polymorphism with a PIC of 0.62. We report localizations of the three polymorphisms on the restriction map of the DRD2 locus. The TaqI RFLPs are in apparent linkage equilibrium with the microsatellite, yielding a highly informative compound marker locus with a PIC of 0.76.

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JO - Genomics

JF - Genomics

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ER -

Detection and characterization of additional DNA polymorphisms in the dopamine D2 receptor gene

Abstract

ASJC Scopus subject areas

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