Design of PDT protocols using delta-aminolevulinic acid (5ALA)

Steven Jacques, Xiao Yan He, Gary Gofstein

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Citations (Scopus)

Abstract

The kinetics of protoporphyrin IX (PPIX) synthesis, bioconversion toother metabolic products, and photobleaching were measured in cell cultures after incubation in media containing the metabolic precursor for heme synthesis. A compartmental model described the kinetics in terms of rate constants for the three processes. Using the information, two dosimetry protocols are outlined which both involve complete photobleaching of the PPIX.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsThomas J. Dougherty, Abraham Katzir
PublisherPubl by Society of Photo-Optical Instrumentation Engineers
Pages99-108 The
Volume1881
ISBN (Print)0819411086
StatePublished - 1993
Externally publishedYes
EventOptical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy II - Los Angeles, CA, USA
Duration: Jan 16 1993Jan 17 1993

Other

OtherOptical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy II
CityLos Angeles, CA, USA
Period1/16/931/17/93

Fingerprint

Photobleaching
bioconversion
Bioconversion
acids
Kinetics
Acids
kinetics
synthesis
Cell culture
Dosimetry
dosimeters
Rate constants
products

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Jacques, S., He, X. Y., & Gofstein, G. (1993). Design of PDT protocols using delta-aminolevulinic acid (5ALA). In T. J. Dougherty, & A. Katzir (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 1881, pp. 99-108 The). Publ by Society of Photo-Optical Instrumentation Engineers.

Design of PDT protocols using delta-aminolevulinic acid (5ALA). / Jacques, Steven; He, Xiao Yan; Gofstein, Gary.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / Thomas J. Dougherty; Abraham Katzir. Vol. 1881 Publ by Society of Photo-Optical Instrumentation Engineers, 1993. p. 99-108 The.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Jacques, S, He, XY & Gofstein, G 1993, Design of PDT protocols using delta-aminolevulinic acid (5ALA). in TJ Dougherty & A Katzir (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 1881, Publ by Society of Photo-Optical Instrumentation Engineers, pp. 99-108 The, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy II, Los Angeles, CA, USA, 1/16/93.
Jacques S, He XY, Gofstein G. Design of PDT protocols using delta-aminolevulinic acid (5ALA). In Dougherty TJ, Katzir A, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 1881. Publ by Society of Photo-Optical Instrumentation Engineers. 1993. p. 99-108 The
Jacques, Steven ; He, Xiao Yan ; Gofstein, Gary. / Design of PDT protocols using delta-aminolevulinic acid (5ALA). Proceedings of SPIE - The International Society for Optical Engineering. editor / Thomas J. Dougherty ; Abraham Katzir. Vol. 1881 Publ by Society of Photo-Optical Instrumentation Engineers, 1993. pp. 99-108 The
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