Design of PDT protocols using delta-aminolevulinic acid (5ALA)

Steven L. Jacques, Xiao Yan He, Gary Gofstein

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Scopus citations

Abstract

The kinetics of protoporphyrin IX (PPIX) synthesis, bioconversion toother metabolic products, and photobleaching were measured in cell cultures after incubation in media containing the metabolic precursor for heme synthesis. A compartmental model described the kinetics in terms of rate constants for the three processes. Using the information, two dosimetry protocols are outlined which both involve complete photobleaching of the PPIX.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsThomas J. Dougherty, Abraham Katzir
PublisherPubl by Society of Photo-Optical Instrumentation Engineers
Pages99-108 The
ISBN (Print)0819411086
StatePublished - Dec 1 1993
Externally publishedYes
EventOptical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy II - Los Angeles, CA, USA
Duration: Jan 16 1993Jan 17 1993

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume1881
ISSN (Print)0277-786X

Other

OtherOptical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy II
CityLos Angeles, CA, USA
Period1/16/931/17/93

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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