Design and testing of an endoscopic photoacoustic probe for determination of treatment depth after photodynamic therapy

J. A. Viator, G. Paltauf, Steven Jacques, S. A. Prahl

Research output: Chapter in Book/Report/Conference proceedingConference contribution

19 Citations (Scopus)

Abstract

An endoscopic photoacoustic probe is designed and tested for use in PDT treatment of esophageal cancer. The probe, measuring less than 2.5 mm in diameter, was designed to fit within the lumen of an endoscope that will be inserted into an esophagous after PDT. PDT treatment results in a blanched, necrotic layer of cancerous tissue over a healthy, deeper layer of perfused tissue. The photoacoustic probe was designed to use acoustic propagation time to determine the thickness of the blanched surface of the esophagous, which corresponds to treatment depth. A side-firing 600 μm fiber delivered 532nm laser light to induce acoustic waves in the perfused layer of the esophagous beneath the blanched (treated) layer. A PVDF transducer detected the induced acoustic waves and transmitted the signal to an oscilloscope. The probe was tested on clear and turbid tissue phantom layers over an optically absorbing dye solution.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsA.A. Oraevsky
Pages16-27
Number of pages12
Volume4256
DOIs
StatePublished - 2001
EventBiomedical Optoacoustics II - San Jose, CA, United States
Duration: Jan 23 2001Jan 24 2001

Other

OtherBiomedical Optoacoustics II
CountryUnited States
CitySan Jose, CA
Period1/23/011/24/01

Fingerprint

Photodynamic therapy
Photoacoustic effect
therapy
probes
Testing
Tissue
Acoustic waves
Endoscopy
acoustic propagation
endoscopes
lumens
acoustics
oscilloscopes
Transducers
Dyes
Acoustics
transducers
dyes
cancer
Fibers

Keywords

  • Acoustic
  • Nd:YAG
  • Optical fiber
  • Propagation time
  • PVDF
  • Q-switched

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Viator, J. A., Paltauf, G., Jacques, S., & Prahl, S. A. (2001). Design and testing of an endoscopic photoacoustic probe for determination of treatment depth after photodynamic therapy. In A. A. Oraevsky (Ed.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 4256, pp. 16-27) https://doi.org/10.1117/12.429311

Design and testing of an endoscopic photoacoustic probe for determination of treatment depth after photodynamic therapy. / Viator, J. A.; Paltauf, G.; Jacques, Steven; Prahl, S. A.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / A.A. Oraevsky. Vol. 4256 2001. p. 16-27.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Viator, JA, Paltauf, G, Jacques, S & Prahl, SA 2001, Design and testing of an endoscopic photoacoustic probe for determination of treatment depth after photodynamic therapy. in AA Oraevsky (ed.), Proceedings of SPIE - The International Society for Optical Engineering. vol. 4256, pp. 16-27, Biomedical Optoacoustics II, San Jose, CA, United States, 1/23/01. https://doi.org/10.1117/12.429311
Viator JA, Paltauf G, Jacques S, Prahl SA. Design and testing of an endoscopic photoacoustic probe for determination of treatment depth after photodynamic therapy. In Oraevsky AA, editor, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 4256. 2001. p. 16-27 https://doi.org/10.1117/12.429311
Viator, J. A. ; Paltauf, G. ; Jacques, Steven ; Prahl, S. A. / Design and testing of an endoscopic photoacoustic probe for determination of treatment depth after photodynamic therapy. Proceedings of SPIE - The International Society for Optical Engineering. editor / A.A. Oraevsky. Vol. 4256 2001. pp. 16-27
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