Design and testing of an endoscopic photoacoustic probe for determination of treatment depth after photodynamic therapy

John A. Viator, Guenther Paltauf, Steven L. Jacques, Scott A. Prahl

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

An endoscopic photoacoustic probe is designed and tested for use in PDT treatment of esophageal cancer. The probe, measuring less than 2.5 mm in diameter, was designed to fit within the lumen of an endoscope that will be inserted into an esophagous after PDT. PDT treatment results in a blanched, necrotic layer of cancerous tissue over a healthy, deeper layer of perfused tissue. The photoacoustic probe was designed to use acoustic propagation time to determine the thickness of the blanched surface of the esophagous, which corresponds to treatment depth. A side-firing 600 μm fiber delivered 532nm laser light to induce acoustic waves in the perfused layer of the esophagous beneath the blanched (treated) layer. A PVDF transducer detected the induced acoustic waves and transmitted the signal to an oscilloscope. The probe was tested on clear and turbid tissue phantom layers over an optically absorbing dye solution.

Original languageEnglish (US)
Pages (from-to)16-27
Number of pages12
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume4256
DOIs
StatePublished - Jan 1 2001

Keywords

  • Acoustic
  • Nd:YAG
  • Optical fiber
  • Propagation time
  • PVDF
  • Q-switched

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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