Design and evaluation of novel nonsteroidal dissociating glucocorticoid receptor ligands

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

A novel class of phenylpyrazole fused Wieland-Miescher ketone derivatives are high affinity, receptor specific, selective modulators of glucocorticoid receptor (GR) function.

Original languageEnglish (US)
Pages (from-to)5199-5203
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume14
Issue number20
DOIs
StatePublished - Oct 18 2004
Externally publishedYes

Fingerprint

Glucocorticoid Receptors
Ketones
Modulators
Ligands
Derivatives

Keywords

  • Glucocorticoid
  • Ligand
  • Nuclear receptor

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Design and evaluation of novel nonsteroidal dissociating glucocorticoid receptor ligands. / Shah, Nilesh; Scanlan, Thomas (Tom).

In: Bioorganic and Medicinal Chemistry Letters, Vol. 14, No. 20, 18.10.2004, p. 5199-5203.

Research output: Contribution to journalArticle

@article{e343b7ce8ca14fd59e62e155c8b11f3d,
title = "Design and evaluation of novel nonsteroidal dissociating glucocorticoid receptor ligands",
abstract = "A novel class of phenylpyrazole fused Wieland-Miescher ketone derivatives are high affinity, receptor specific, selective modulators of glucocorticoid receptor (GR) function.",
keywords = "Glucocorticoid, Ligand, Nuclear receptor",
author = "Nilesh Shah and Scanlan, {Thomas (Tom)}",
year = "2004",
month = "10",
day = "18",
doi = "10.1016/j.bmcl.2004.07.052",
language = "English (US)",
volume = "14",
pages = "5199--5203",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "20",

}

TY - JOUR

T1 - Design and evaluation of novel nonsteroidal dissociating glucocorticoid receptor ligands

AU - Shah, Nilesh

AU - Scanlan, Thomas (Tom)

PY - 2004/10/18

Y1 - 2004/10/18

N2 - A novel class of phenylpyrazole fused Wieland-Miescher ketone derivatives are high affinity, receptor specific, selective modulators of glucocorticoid receptor (GR) function.

AB - A novel class of phenylpyrazole fused Wieland-Miescher ketone derivatives are high affinity, receptor specific, selective modulators of glucocorticoid receptor (GR) function.

KW - Glucocorticoid

KW - Ligand

KW - Nuclear receptor

UR - http://www.scopus.com/inward/record.url?scp=4544343929&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4544343929&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2004.07.052

DO - 10.1016/j.bmcl.2004.07.052

M3 - Article

C2 - 15380227

AN - SCOPUS:4544343929

VL - 14

SP - 5199

EP - 5203

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 20

ER -