Design and evaluation of novel nonsteroidal dissociating glucocorticoid receptor ligands

Nilesh Shah; Thomas S. Scanlan

doi:10.1016/j.bmcl.2004.07.052

Design and evaluation of novel nonsteroidal dissociating glucocorticoid receptor ligands

Nilesh Shah, Thomas S. Scanlan

Research output: Contribution to journal › Article › peer-review

76 Scopus citations

Abstract

A novel class of phenylpyrazole fused Wieland-Miescher ketone derivatives are high affinity, receptor specific, selective modulators of glucocorticoid receptor (GR) function.

Original language	English (US)
Pages (from-to)	5199-5203
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	14
Issue number	20
DOIs	https://doi.org/10.1016/j.bmcl.2004.07.052
State	Published - Oct 18 2004
Externally published	Yes

Keywords

Glucocorticoid
Ligand
Nuclear receptor

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2004.07.052

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title = "Design and evaluation of novel nonsteroidal dissociating glucocorticoid receptor ligands",

abstract = "A novel class of phenylpyrazole fused Wieland-Miescher ketone derivatives are high affinity, receptor specific, selective modulators of glucocorticoid receptor (GR) function.",

keywords = "Glucocorticoid, Ligand, Nuclear receptor",

author = "Nilesh Shah and Scanlan, {Thomas S.}",

note = "Funding Information: We are grateful to I. Rogatsky, B. Darimont, and H. Luecke for plasmids. Research support was from the National Institutes of Health (DK 57574).",

year = "2004",

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doi = "10.1016/j.bmcl.2004.07.052",

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AU - Shah, Nilesh

AU - Scanlan, Thomas S.

N1 - Funding Information: We are grateful to I. Rogatsky, B. Darimont, and H. Luecke for plasmids. Research support was from the National Institutes of Health (DK 57574).

PY - 2004/10/18

Y1 - 2004/10/18

N2 - A novel class of phenylpyrazole fused Wieland-Miescher ketone derivatives are high affinity, receptor specific, selective modulators of glucocorticoid receptor (GR) function.

AB - A novel class of phenylpyrazole fused Wieland-Miescher ketone derivatives are high affinity, receptor specific, selective modulators of glucocorticoid receptor (GR) function.

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KW - Ligand

KW - Nuclear receptor

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

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ER -

Design and evaluation of novel nonsteroidal dissociating glucocorticoid receptor ligands

Abstract

Keywords

ASJC Scopus subject areas

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