Deregulation of cyclin E meets dysfunction in p53: Closing the escape hatch on breast cancer

Michelle Craig Barton, Said Akli, Khandan Keyomarsi

Research output: Contribution to journalShort surveypeer-review

20 Scopus citations

Abstract

In this review, we focus on pathways intersecting through p53 and cyclin E, highlighting how oncogenic effects of cyclin E deregulation, especially overexpression of shortened or low molecular weight (LMW) forms of cyclin E protein, are amplified by loss of regulatory control through p53 to promote tumor development. Expression of cyclin E protein promotes progression into S-phase, an activity opposed by p53-regulated activation of checkpoint controls or apoptosis. Loss of p53 function is an escape hatch by which tumor cells, initiated by a number of means including cyclin E deregulation, can avoid cell cycle arrest or cell death and progress through further stages of unchecked deregulation and growth. To determine how this escape hatch is opened and, ultimately, how to close it, we must understand the networks of normal signaling and processing in a cell and where they intersect.

Original languageEnglish (US)
Pages (from-to)686-694
Number of pages9
JournalJournal of Cellular Physiology
Volume209
Issue number3
DOIs
StatePublished - Dec 2006
Externally publishedYes

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Cell Biology

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