Derailed endocytosis: An emerging feature of cancer

Yaron Mosesson, Gordon B. Mills, Yosef Yarden

Research output: Contribution to journalReview articlepeer-review

492 Scopus citations

Abstract

Once engaged by soluble or matrix-anchored ligands, cell surface proteins are commonly sorted to lysosomal degradation through several endocytic pathways. Defective vesicular trafficking of growth factor receptors, as well as unbalanced recycling of integrin- and cadherin-based adhesion complexes, has emerged in the past 5 years as a multifaceted hallmark of malignant cells. In line with the cooperative nature of endocytic machineries, multiple oncogenic alterations underlie defective endocytosis, such as altered ubiquitylation (Cbl and Nedd4 ubiquitin ligases, for example), altered cytoskeletal interactions and alterations to Rab family members. Pharmaceutical interception of the propensity of tumour cells to derail their signalling and their adhesion receptors may constitute a novel target for cancer therapy.

Original languageEnglish (US)
Pages (from-to)835-850
Number of pages16
JournalNature Reviews Cancer
Volume8
Issue number11
DOIs
StatePublished - Nov 2008
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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