Depth-resolved optical imaging of hemodynamic response in mouse brain within microcirculatory beds

Jia Yali, Rosemary Nettleton, Mara Rosenberg, Eilis Boudreau, Ruikang K. Wang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Optical hemodynamic imaging employed in pre-clinical studies with high spatial and temporal resolution is significant to unveil the functional activities of brain and the mechanism of internal or external stimulus effects in diverse pathological conditions and treatments. Most current optical systems only resolve hemodynamic changes within superficial macro-circulatory beds, such as laser speckle contrast imaging; or only provide vascular structural information within micro-circulatory beds, such as multi-photon microscopy. In this study, we introduce a hemodynamic imaging system based on Optical Micro-angiography (OMAG) which is capable of resolving and quantifying 3D dynamic blood perfusion down to microcirculatory level. This system can measure the optical phase shifts caused by moving blood cells in microcirculation. Here, the utility of OMAG was demonstrated by monitoring the hemodynamic response to alcohol administration in mouse prefrontal cortex. Our preliminary results suggest that the spatiotemporal tracking of cerebral micro-hemodynamic using OMAG can be successfully applied to the mouse brain and reliably distinguish between vehicle and alcohol stimulation experiment.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7898
DOIs
StatePublished - 2011
EventDynamics and Fluctuations in Biomedical Photonics VIII - San Francisco, CA, United States
Duration: Jan 22 2011Jan 24 2011

Other

OtherDynamics and Fluctuations in Biomedical Photonics VIII
CountryUnited States
CitySan Francisco, CA
Period1/22/111/24/11

Fingerprint

hemodynamic responses
hemodynamics
Optical Imaging
Hemodynamics
optical thickness
brain
mice
angiography
beds
Brain
Angiography
Imaging techniques
alcohols
Alcohols
Blood
blood cells
cortexes
Microcirculation
Optical Devices
temporal resolution

Keywords

  • Hemodynamic response
  • Microcirculation
  • Optical microangiography

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Yali, J., Nettleton, R., Rosenberg, M., Boudreau, E., & Wang, R. K. (2011). Depth-resolved optical imaging of hemodynamic response in mouse brain within microcirculatory beds. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 7898). [789812] https://doi.org/10.1117/12.874232

Depth-resolved optical imaging of hemodynamic response in mouse brain within microcirculatory beds. / Yali, Jia; Nettleton, Rosemary; Rosenberg, Mara; Boudreau, Eilis; Wang, Ruikang K.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7898 2011. 789812.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Yali, J, Nettleton, R, Rosenberg, M, Boudreau, E & Wang, RK 2011, Depth-resolved optical imaging of hemodynamic response in mouse brain within microcirculatory beds. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 7898, 789812, Dynamics and Fluctuations in Biomedical Photonics VIII, San Francisco, CA, United States, 1/22/11. https://doi.org/10.1117/12.874232
Yali J, Nettleton R, Rosenberg M, Boudreau E, Wang RK. Depth-resolved optical imaging of hemodynamic response in mouse brain within microcirculatory beds. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7898. 2011. 789812 https://doi.org/10.1117/12.874232
Yali, Jia ; Nettleton, Rosemary ; Rosenberg, Mara ; Boudreau, Eilis ; Wang, Ruikang K. / Depth-resolved optical imaging of hemodynamic response in mouse brain within microcirculatory beds. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7898 2011.
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