Depressive symptoms in patients with chronic hepatitis C are correlated with elevated plasma levels of interleukin-1β and tumor necrosis factor-α

Jennifer Loftis, Marilyn Huckans, Samantha Ruimy, David J. Hinrichs, Peter Hauser

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

Studies suggest that cytokines have a role in the biology of depression. In this study, we evaluated depression and cytokine levels in patients with and without chronic hepatitis C (HCV) to better assess how chronic infection alters cytokines levels and may contribute to depressive symptomotology. Twenty-three adults with (n = 16) and without (n = 7) HCV were recruited through the Portland VA Medical Center. Research participants were excluded for current substance abuse, psychotic disorder, liver cirrhosis, or interferon (IFN) therapy. Participants completed the Beck Depression Inventory-II (BDI-II) and a blood draw to evaluate plasma cytokine levels [i.e., interleukin (IL)-1β, IL-10 and tumor necrosis factor (TNF)-α]. t-Tests were performed to compare cytokine levels in patients with or without HCV. HCV patients showed higher TNF-α values compared to patients without HCV (group means = 7.94 vs. 3.41 pg/mL, respectively, p = 0.047). There were no significant differences between the groups for the other cytokines assessed. In patients with HCV, TNF-α and IL-1β levels (but not IL-10) were correlated with BDI-II scores [r = 0.594, p = 0.020 and r = 0.489, p = 0.055 (trend), respectively]. Taken together, these results show an association between severity of depressive symptoms and expression of pro-inflammatory cytokines in patients with HCV. Future studies should investigate how inflammatory mediators play a role in the expression of specific depressive symptoms in patients with chronic infection. Patients with HCV represent an interesting model to examine this relationship.

Original languageEnglish (US)
Pages (from-to)264-268
Number of pages5
JournalNeuroscience Letters
Volume430
Issue number3
DOIs
StatePublished - Jan 17 2008

Fingerprint

Chronic Hepatitis C
Interleukin-1
Tumor Necrosis Factor-alpha
Depression
Cytokines
Interleukin-10
Equipment and Supplies
Infection
Liver Cirrhosis
Psychotic Disorders
Interferons
Substance-Related Disorders
Research

Keywords

  • Beck Depression Inventory
  • Chronic infection
  • Cytokines
  • Hypothalamic-pituitary-adrenal axis
  • Inflammation
  • Serotonin

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Depressive symptoms in patients with chronic hepatitis C are correlated with elevated plasma levels of interleukin-1β and tumor necrosis factor-α. / Loftis, Jennifer; Huckans, Marilyn; Ruimy, Samantha; Hinrichs, David J.; Hauser, Peter.

In: Neuroscience Letters, Vol. 430, No. 3, 17.01.2008, p. 264-268.

Research output: Contribution to journalArticle

@article{4f27652e17b849d99ff505aa4283d5c6,
title = "Depressive symptoms in patients with chronic hepatitis C are correlated with elevated plasma levels of interleukin-1β and tumor necrosis factor-α",
abstract = "Studies suggest that cytokines have a role in the biology of depression. In this study, we evaluated depression and cytokine levels in patients with and without chronic hepatitis C (HCV) to better assess how chronic infection alters cytokines levels and may contribute to depressive symptomotology. Twenty-three adults with (n = 16) and without (n = 7) HCV were recruited through the Portland VA Medical Center. Research participants were excluded for current substance abuse, psychotic disorder, liver cirrhosis, or interferon (IFN) therapy. Participants completed the Beck Depression Inventory-II (BDI-II) and a blood draw to evaluate plasma cytokine levels [i.e., interleukin (IL)-1β, IL-10 and tumor necrosis factor (TNF)-α]. t-Tests were performed to compare cytokine levels in patients with or without HCV. HCV patients showed higher TNF-α values compared to patients without HCV (group means = 7.94 vs. 3.41 pg/mL, respectively, p = 0.047). There were no significant differences between the groups for the other cytokines assessed. In patients with HCV, TNF-α and IL-1β levels (but not IL-10) were correlated with BDI-II scores [r = 0.594, p = 0.020 and r = 0.489, p = 0.055 (trend), respectively]. Taken together, these results show an association between severity of depressive symptoms and expression of pro-inflammatory cytokines in patients with HCV. Future studies should investigate how inflammatory mediators play a role in the expression of specific depressive symptoms in patients with chronic infection. Patients with HCV represent an interesting model to examine this relationship.",
keywords = "Beck Depression Inventory, Chronic infection, Cytokines, Hypothalamic-pituitary-adrenal axis, Inflammation, Serotonin",
author = "Jennifer Loftis and Marilyn Huckans and Samantha Ruimy and Hinrichs, {David J.} and Peter Hauser",
year = "2008",
month = "1",
day = "17",
doi = "10.1016/j.neulet.2007.11.001",
language = "English (US)",
volume = "430",
pages = "264--268",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

TY - JOUR

T1 - Depressive symptoms in patients with chronic hepatitis C are correlated with elevated plasma levels of interleukin-1β and tumor necrosis factor-α

AU - Loftis, Jennifer

AU - Huckans, Marilyn

AU - Ruimy, Samantha

AU - Hinrichs, David J.

AU - Hauser, Peter

PY - 2008/1/17

Y1 - 2008/1/17

N2 - Studies suggest that cytokines have a role in the biology of depression. In this study, we evaluated depression and cytokine levels in patients with and without chronic hepatitis C (HCV) to better assess how chronic infection alters cytokines levels and may contribute to depressive symptomotology. Twenty-three adults with (n = 16) and without (n = 7) HCV were recruited through the Portland VA Medical Center. Research participants were excluded for current substance abuse, psychotic disorder, liver cirrhosis, or interferon (IFN) therapy. Participants completed the Beck Depression Inventory-II (BDI-II) and a blood draw to evaluate plasma cytokine levels [i.e., interleukin (IL)-1β, IL-10 and tumor necrosis factor (TNF)-α]. t-Tests were performed to compare cytokine levels in patients with or without HCV. HCV patients showed higher TNF-α values compared to patients without HCV (group means = 7.94 vs. 3.41 pg/mL, respectively, p = 0.047). There were no significant differences between the groups for the other cytokines assessed. In patients with HCV, TNF-α and IL-1β levels (but not IL-10) were correlated with BDI-II scores [r = 0.594, p = 0.020 and r = 0.489, p = 0.055 (trend), respectively]. Taken together, these results show an association between severity of depressive symptoms and expression of pro-inflammatory cytokines in patients with HCV. Future studies should investigate how inflammatory mediators play a role in the expression of specific depressive symptoms in patients with chronic infection. Patients with HCV represent an interesting model to examine this relationship.

AB - Studies suggest that cytokines have a role in the biology of depression. In this study, we evaluated depression and cytokine levels in patients with and without chronic hepatitis C (HCV) to better assess how chronic infection alters cytokines levels and may contribute to depressive symptomotology. Twenty-three adults with (n = 16) and without (n = 7) HCV were recruited through the Portland VA Medical Center. Research participants were excluded for current substance abuse, psychotic disorder, liver cirrhosis, or interferon (IFN) therapy. Participants completed the Beck Depression Inventory-II (BDI-II) and a blood draw to evaluate plasma cytokine levels [i.e., interleukin (IL)-1β, IL-10 and tumor necrosis factor (TNF)-α]. t-Tests were performed to compare cytokine levels in patients with or without HCV. HCV patients showed higher TNF-α values compared to patients without HCV (group means = 7.94 vs. 3.41 pg/mL, respectively, p = 0.047). There were no significant differences between the groups for the other cytokines assessed. In patients with HCV, TNF-α and IL-1β levels (but not IL-10) were correlated with BDI-II scores [r = 0.594, p = 0.020 and r = 0.489, p = 0.055 (trend), respectively]. Taken together, these results show an association between severity of depressive symptoms and expression of pro-inflammatory cytokines in patients with HCV. Future studies should investigate how inflammatory mediators play a role in the expression of specific depressive symptoms in patients with chronic infection. Patients with HCV represent an interesting model to examine this relationship.

KW - Beck Depression Inventory

KW - Chronic infection

KW - Cytokines

KW - Hypothalamic-pituitary-adrenal axis

KW - Inflammation

KW - Serotonin

UR - http://www.scopus.com/inward/record.url?scp=38049153269&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38049153269&partnerID=8YFLogxK

U2 - 10.1016/j.neulet.2007.11.001

DO - 10.1016/j.neulet.2007.11.001

M3 - Article

VL - 430

SP - 264

EP - 268

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 3

ER -