Depressive Symptoms in Children with Chronic Kidney Disease

Chronic Kidney Disease in Children (CKiD) Study Group

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective To assess depression in children with chronic kidney disease and to determine associations with patient characteristics, intellectual and educational levels, and health-related quality of life (HRQoL). Study design Subjects aged 6-17 years from the Chronic Kidney Disease in Children cohort study completed the Children's Depression Inventory (CDI), Wechsler Abbreviated Scales of Intelligence, Wechsler Individual Achievement Test-II-Abbreviated, and the Pediatric Inventory of Quality of Life Core Scales 4.0. Regression analyses determined associations of CDI score and depression status with subject characteristics, intellectual and educational levels, and HRQoL. A joint linear mixed model and Weibull model were used to determine the effects of CDI score on longitudinal changes in glomerular filtration rate and time to renal replacement therapy. Results A total of 344 subjects completed the CDI. Eighteen (5%) had elevated depressive symptoms, and another 7 (2%) were being treated for depression. In adjusted analyses, maternal education beyond high school was associated with 5% lower CDI scores (estimate, 0.95; 95% CI, 0.92-0.99). Depression status was associated with lower IQ (99 vs 88; P =.053), lower achievement (95 vs 77.5; P

Original languageEnglish (US)
Pages (from-to)164-170
Number of pages7
JournalJournal of Pediatrics
Volume168
DOIs
StatePublished - Jan 1 2016

Fingerprint

Chronic Renal Insufficiency
Depression
Equipment and Supplies
Quality of Life
Health Status
Wechsler Scales
Renal Replacement Therapy
Glomerular Filtration Rate
Intelligence
Linear Models
Cohort Studies
Joints
Regression Analysis
Mothers
Pediatrics
Education

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Depressive Symptoms in Children with Chronic Kidney Disease. / Chronic Kidney Disease in Children (CKiD) Study Group.

In: Journal of Pediatrics, Vol. 168, 01.01.2016, p. 164-170.

Research output: Contribution to journalArticle

Chronic Kidney Disease in Children (CKiD) Study Group 2016, 'Depressive Symptoms in Children with Chronic Kidney Disease', Journal of Pediatrics, vol. 168, pp. 164-170. https://doi.org/10.1016/j.jpeds.2015.09.040
Chronic Kidney Disease in Children (CKiD) Study Group. Depressive Symptoms in Children with Chronic Kidney Disease. Journal of Pediatrics. 2016 Jan 1;168:164-170. https://doi.org/10.1016/j.jpeds.2015.09.040
Chronic Kidney Disease in Children (CKiD) Study Group. / Depressive Symptoms in Children with Chronic Kidney Disease. In: Journal of Pediatrics. 2016 ; Vol. 168. pp. 164-170.
@article{728a5f380fe94bf5aa117ed339304d88,
title = "Depressive Symptoms in Children with Chronic Kidney Disease",
abstract = "Objective To assess depression in children with chronic kidney disease and to determine associations with patient characteristics, intellectual and educational levels, and health-related quality of life (HRQoL). Study design Subjects aged 6-17 years from the Chronic Kidney Disease in Children cohort study completed the Children's Depression Inventory (CDI), Wechsler Abbreviated Scales of Intelligence, Wechsler Individual Achievement Test-II-Abbreviated, and the Pediatric Inventory of Quality of Life Core Scales 4.0. Regression analyses determined associations of CDI score and depression status with subject characteristics, intellectual and educational levels, and HRQoL. A joint linear mixed model and Weibull model were used to determine the effects of CDI score on longitudinal changes in glomerular filtration rate and time to renal replacement therapy. Results A total of 344 subjects completed the CDI. Eighteen (5{\%}) had elevated depressive symptoms, and another 7 (2{\%}) were being treated for depression. In adjusted analyses, maternal education beyond high school was associated with 5{\%} lower CDI scores (estimate, 0.95; 95{\%} CI, 0.92-0.99). Depression status was associated with lower IQ (99 vs 88; P =.053), lower achievement (95 vs 77.5; P",
author = "{Chronic Kidney Disease in Children (CKiD) Study Group} and Kogon, {Amy J.} and Matheson, {Matthew B.} and Flynn, {Joseph T.} and Gerson, {Arlene C.} and Warady, {Bradley A.} and Furth, {Susan L.} and Hooper, {Stephen R.} and Allison Dart and Larry Greenbaum and Jens Goebel and Mark Mitsnefes and Craig Wong and Sahar Fathallah and Isidro Salusky and Ora Yadin and Katherine Dell and Bruce Morgenstern and Tom Blydt-Hansen and Cynthia Pan and Keefe Davis and Amira Al-Uzri and Randall Jenkins and Anthony Portale and Mouin Seikaly and Martin Turman and Cynthia Wong and Steven Alexander and Colleen Hastings and Nancy Rodig and William Harmon and Sharon Bartosh and Nadine Benador and Robert Mak and Ellen Wood and Gary Lerner and Susan Massengill and Guillermo Hidalgo and Meredith Atkinson and Debbie Gipson and Poyyapakkam Srivaths and Joshua Samuels and Frederick Kaskel and Debora Mattosian and Yi Cai and Sharon Andreoli and Jeffrey Saland and Victoria Norwood and Rulan Parekh and Lisa Robinson and Susan Mendley",
year = "2016",
month = "1",
day = "1",
doi = "10.1016/j.jpeds.2015.09.040",
language = "English (US)",
volume = "168",
pages = "164--170",
journal = "Journal of Pediatrics",
issn = "0022-3476",
publisher = "Mosby Inc.",

}

TY - JOUR

T1 - Depressive Symptoms in Children with Chronic Kidney Disease

AU - Chronic Kidney Disease in Children (CKiD) Study Group

AU - Kogon, Amy J.

AU - Matheson, Matthew B.

AU - Flynn, Joseph T.

AU - Gerson, Arlene C.

AU - Warady, Bradley A.

AU - Furth, Susan L.

AU - Hooper, Stephen R.

AU - Dart, Allison

AU - Greenbaum, Larry

AU - Goebel, Jens

AU - Mitsnefes, Mark

AU - Wong, Craig

AU - Fathallah, Sahar

AU - Salusky, Isidro

AU - Yadin, Ora

AU - Dell, Katherine

AU - Morgenstern, Bruce

AU - Blydt-Hansen, Tom

AU - Pan, Cynthia

AU - Davis, Keefe

AU - Al-Uzri, Amira

AU - Jenkins, Randall

AU - Portale, Anthony

AU - Seikaly, Mouin

AU - Turman, Martin

AU - Wong, Cynthia

AU - Alexander, Steven

AU - Hastings, Colleen

AU - Rodig, Nancy

AU - Harmon, William

AU - Bartosh, Sharon

AU - Benador, Nadine

AU - Mak, Robert

AU - Wood, Ellen

AU - Lerner, Gary

AU - Massengill, Susan

AU - Hidalgo, Guillermo

AU - Atkinson, Meredith

AU - Gipson, Debbie

AU - Srivaths, Poyyapakkam

AU - Samuels, Joshua

AU - Kaskel, Frederick

AU - Mattosian, Debora

AU - Cai, Yi

AU - Andreoli, Sharon

AU - Saland, Jeffrey

AU - Norwood, Victoria

AU - Parekh, Rulan

AU - Robinson, Lisa

AU - Mendley, Susan

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Objective To assess depression in children with chronic kidney disease and to determine associations with patient characteristics, intellectual and educational levels, and health-related quality of life (HRQoL). Study design Subjects aged 6-17 years from the Chronic Kidney Disease in Children cohort study completed the Children's Depression Inventory (CDI), Wechsler Abbreviated Scales of Intelligence, Wechsler Individual Achievement Test-II-Abbreviated, and the Pediatric Inventory of Quality of Life Core Scales 4.0. Regression analyses determined associations of CDI score and depression status with subject characteristics, intellectual and educational levels, and HRQoL. A joint linear mixed model and Weibull model were used to determine the effects of CDI score on longitudinal changes in glomerular filtration rate and time to renal replacement therapy. Results A total of 344 subjects completed the CDI. Eighteen (5%) had elevated depressive symptoms, and another 7 (2%) were being treated for depression. In adjusted analyses, maternal education beyond high school was associated with 5% lower CDI scores (estimate, 0.95; 95% CI, 0.92-0.99). Depression status was associated with lower IQ (99 vs 88; P =.053), lower achievement (95 vs 77.5; P

AB - Objective To assess depression in children with chronic kidney disease and to determine associations with patient characteristics, intellectual and educational levels, and health-related quality of life (HRQoL). Study design Subjects aged 6-17 years from the Chronic Kidney Disease in Children cohort study completed the Children's Depression Inventory (CDI), Wechsler Abbreviated Scales of Intelligence, Wechsler Individual Achievement Test-II-Abbreviated, and the Pediatric Inventory of Quality of Life Core Scales 4.0. Regression analyses determined associations of CDI score and depression status with subject characteristics, intellectual and educational levels, and HRQoL. A joint linear mixed model and Weibull model were used to determine the effects of CDI score on longitudinal changes in glomerular filtration rate and time to renal replacement therapy. Results A total of 344 subjects completed the CDI. Eighteen (5%) had elevated depressive symptoms, and another 7 (2%) were being treated for depression. In adjusted analyses, maternal education beyond high school was associated with 5% lower CDI scores (estimate, 0.95; 95% CI, 0.92-0.99). Depression status was associated with lower IQ (99 vs 88; P =.053), lower achievement (95 vs 77.5; P

UR - http://www.scopus.com/inward/record.url?scp=84955677487&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84955677487&partnerID=8YFLogxK

U2 - 10.1016/j.jpeds.2015.09.040

DO - 10.1016/j.jpeds.2015.09.040

M3 - Article

C2 - 26505290

AN - SCOPUS:84955677487

VL - 168

SP - 164

EP - 170

JO - Journal of Pediatrics

JF - Journal of Pediatrics

SN - 0022-3476

ER -