Depressive symptoms and rates of bone loss at the hip in older men

S. J. Diem, S. L. Harrison, Elizabeth Haney, J. A. Cauley, K. L. Stone, Eric Orwoll, K. E. Ensrud

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

In this prospective cohort study, depressive symptoms were associated with higher rates of bone loss in older men. Poorer performance on physical function tests partly explained the association between depressive symptoms and bone loss, suggesting that efforts to increase exercise and improve physical performance in depressed men may be beneficial. Introduction: The aim of this study was to ascertain whether depressive symptoms are associated with increased rates of bone loss at the hip in older men. Methods: A population-based prospective cohort study of 2,464 community-dwelling men, aged 68 and older, enrolled in the Osteoporosis in Men Sleep Ancillary Study had depressive symptoms assessed by the Geriatric Depression Scale (GDS). Subjects were categorized as depressed if GDS ≥6 at the initial examination. Bone mineral density (BMD) at the hip was measured using dual-energy X-ray absorptiometry at the initial and follow-up examination (average 3.4 years between exams). Use of antidepressant medications was assessed by interview and verified from medication containers at the two examinations. A computerized dictionary was used to categorize type of medication. Results: In a base model adjusted for age, race/ethnicity, and clinic site, the mean total hip BMD decreased 0.70 %/year in 136 men with a GDS score of ≥6 compared to 0.39 %/year in 2,328 men with a GDS score of

Original languageEnglish (US)
Pages (from-to)111-119
Number of pages9
JournalOsteoporosis International
Volume24
Issue number1
DOIs
StatePublished - Jan 2013

Fingerprint

Hip
Depression
Bone and Bones
Geriatrics
Bone Density
Cohort Studies
Pelvic Bones
Prospective Studies
Independent Living
Photon Absorptiometry
Antidepressive Agents
Osteoporosis
Sleep
Interviews
Exercise
Population

Keywords

  • Bone mineral density
  • Depression
  • Elderly men
  • Osteoporosis
  • Physical function

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Depressive symptoms and rates of bone loss at the hip in older men. / Diem, S. J.; Harrison, S. L.; Haney, Elizabeth; Cauley, J. A.; Stone, K. L.; Orwoll, Eric; Ensrud, K. E.

In: Osteoporosis International, Vol. 24, No. 1, 01.2013, p. 111-119.

Research output: Contribution to journalArticle

Diem, S. J. ; Harrison, S. L. ; Haney, Elizabeth ; Cauley, J. A. ; Stone, K. L. ; Orwoll, Eric ; Ensrud, K. E. / Depressive symptoms and rates of bone loss at the hip in older men. In: Osteoporosis International. 2013 ; Vol. 24, No. 1. pp. 111-119.
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