Depression-specific outcomes after treatment of chronic rhinosinusitis

Rodney J. Schlosser, J. Madison Hyer, Timothy Smith, Jess C. Mace, Bernadette M. Cortese, Thomas W. Uhde, Luke Rudmik, Zachary M. Soler

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21 Scopus citations


IMPORTANCE: Depression is frequently undiagnosed in patients with chronic rhinosinusitis (CRS) and affects quality of life, productivity, and health care use. OBJECTIVE: To examine depression-specific outcomes after medical or surgical treatment of CRS. DESIGN, SETTING, AND PARTICIPANTS: A multi-institutional, prospective study of patients with refractory CRS treated at tertiary academic rhinology centers was performed from March 1, 2011, to November 1, 2015. Data analysis was performed from October 1, 2015, to November 1, 2015. INTERVENTIONS: Patients self-selected to undergo continued medical management or endoscopic sinus surgery for refractory CRS. MAIN OUTCOMES AND MEASURES: Patients completed the 22-item Sinonasal Outcome Test (SNOT22), Rhinosinusitis Disability Index (RSDI), Pittsburgh Sleep Quality Index (PSQI), and missed productivity and medication use questionnaires before and at least 6 months after treatment. Computed tomography and endoscopy scoring were performed with reviewers masked to patient-reported data. Depression-specific outcomes were recorded using the 2-item Patient Health Questionnaire (PHQ2). RESULTS: Baseline data were available on 685 patients, with 167 (24.4%) having depression according to the PHQ2 scores. The mean (SD) age of the patients was 50.5 (15.0) years, and 332 (48.4%) were male. Revision surgery status was the only baseline factor associated with depression (53.9% vs 38.0%, P

Original languageEnglish (US)
Pages (from-to)370-376
Number of pages7
JournalJAMA Otolaryngology - Head and Neck Surgery
Issue number4
StatePublished - Apr 1 2016

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Surgery

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    Schlosser, R. J., Hyer, J. M., Smith, T., Mace, J. C., Cortese, B. M., Uhde, T. W., Rudmik, L., & Soler, Z. M. (2016). Depression-specific outcomes after treatment of chronic rhinosinusitis. JAMA Otolaryngology - Head and Neck Surgery, 142(4), 370-376.