Depression of thalamic metabolism by lorazepam is associated with sleepiness

Nora D. Volkow, Gene Jack Wang, Robert Hitzemann, Joanna S. Fowler, Naome Pappas, Patricia Lowrimore, Gail Burr, Katherine Pascani, John Overall, Alfred P. Wolf

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Though it is well recognized that the pharmacological actions of benzodiazepines are mediated by facilitation of GABAergic neurotransmission, the consequences of these changes in regional brain function are not well understood. This study measured regional brain glucose metabolism using Positron Emission Tomography and 2-deoxy-2[18F]fluoro-D-glucose in normal controls (n= 21) investigated with and without lorazepam (30 μg/kg IV) and with flumazenil given after lorazepam (n=9). Lorazepam markedly decreased metabolism in thalamus (23/+-8%) and occipital cortex (19±8%), and flumazenil partially reversed these changes. Changes in metabolic activity in thalamus were significantly correlated with lorazepam-induced sleepiness (t=.69, df 20, p

Original languageEnglish (US)
Pages (from-to)123-132
Number of pages10
JournalNeuropsychopharmacology
Volume12
Issue number2
DOIs
StatePublished - 1995
Externally publishedYes

Fingerprint

Lorazepam
Flumazenil
Thalamus
Occipital Lobe
Fluorodeoxyglucose F18
Brain
Benzodiazepines
Synaptic Transmission
Positron-Emission Tomography
Pharmacology
Glucose

Keywords

  • Benzodiazepines
  • Brain glucose metabolism
  • Positron emission tomography
  • Sedation
  • Thalamus

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology

Cite this

Volkow, N. D., Wang, G. J., Hitzemann, R., Fowler, J. S., Pappas, N., Lowrimore, P., ... Wolf, A. P. (1995). Depression of thalamic metabolism by lorazepam is associated with sleepiness. Neuropsychopharmacology, 12(2), 123-132. https://doi.org/10.1016/0893-133X(94)00068-B

Depression of thalamic metabolism by lorazepam is associated with sleepiness. / Volkow, Nora D.; Wang, Gene Jack; Hitzemann, Robert; Fowler, Joanna S.; Pappas, Naome; Lowrimore, Patricia; Burr, Gail; Pascani, Katherine; Overall, John; Wolf, Alfred P.

In: Neuropsychopharmacology, Vol. 12, No. 2, 1995, p. 123-132.

Research output: Contribution to journalArticle

Volkow, ND, Wang, GJ, Hitzemann, R, Fowler, JS, Pappas, N, Lowrimore, P, Burr, G, Pascani, K, Overall, J & Wolf, AP 1995, 'Depression of thalamic metabolism by lorazepam is associated with sleepiness', Neuropsychopharmacology, vol. 12, no. 2, pp. 123-132. https://doi.org/10.1016/0893-133X(94)00068-B
Volkow, Nora D. ; Wang, Gene Jack ; Hitzemann, Robert ; Fowler, Joanna S. ; Pappas, Naome ; Lowrimore, Patricia ; Burr, Gail ; Pascani, Katherine ; Overall, John ; Wolf, Alfred P. / Depression of thalamic metabolism by lorazepam is associated with sleepiness. In: Neuropsychopharmacology. 1995 ; Vol. 12, No. 2. pp. 123-132.
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